Lauri Aaltonen

1963 -

country of citizenship: Finland

educated at: University of Helsinki

occupation: geneticist

award received: Matti Äyräpää Prize, Anders Jahre's Awards for Medical Research

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Articles 211

Date

Title

Authors

2021-09-14

Parity associates with chromosomal damage in uterine leiomyomas

Kristiina Rajamäki, Jaana Tolvanen, Kimmo Palin, Netta Mäkinen, Jussi Taipale, Liisa Kauppi, Manuela Tumiati, Antti Hassinen, Jyrki Jalkanen, Sanna Heikkinen, Annukka Pasanen, Ralf Bützow, Niko Välimäki, Lauri Aaltonen
2021-07-23

Human cell transformation by combined lineage conversion and oncogene expression

Biswajyoti Sahu, Päivi Pihlajamaa, Kimmo Palin, Alejandra Cervera, Lauri Aaltonen, Sampsa Hautaniemi, Jussi Taipale
2020-07-23

Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions

E-V Wirta, Toni T Seppälä, Ulrika A Hänninen, Jukka-Pekka Mecklin, Lauri Aaltonen
2020-12-31

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Lauri Aaltonen
2019-05-14

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Philip J. Law, Maria Timofeeva, Ceres Fernández-rozadilla, Peter Broderick, James Studd, Susan M Farrington, Victoria Svinti, Amit Sud, Caroline Hayward, Archie I Campbell, Claudia M A Pinna, Lynn Martin, James E East, Richard S Kaplan, Nada Al Tassan, Kimmo Palin, Tatiana Cajuso, Veikko Salomaa, Anna Lepistö, Jukka-Pekka Mecklin, Daniel D Buchanan, Aung Ko Win, Mark Jenkins, Douglas F. Easton, Paul D P Pharoah, Federico Canzian, Rosalind Eeles, Kenneth Muir, Nora Pashayan, Andrea Harkin, James Paul, Michael Hoffmeister, Philipp Hofer, Stefanie Brezina, Jeremy P Cheadle, Ian Tomlinson, Richard Houlston, Steven Garcia, Polly A Newcomb, Anthony Swerdlow, Ulrika A Hänninen, PG Vaughan-Shaw, Rachel S Kerr, Malcolm G. Dunlop, Aarno Palotie, Lauri Aaltonen, Hermann Brenner, Zsofia Kote-Jarai, Laura Renkonen-Sinisalo, Johan G. Eriksson, Noralane Lindor, Ian Deary, Markus M Nöthen, Per Hoffmann, John Hopper, Steven Penegar, David Duggan, Harry Campbell, John M Starr, Iva Kirac, Tomas Tanskanen, Johanna Kondelin, Antti-Pekka Sarin, Harri Rissanen, Paul Knekt, Pekka Jousilahti, Amy Twigger Holroyd, Giulia Orlando, Tim S Maughan, Jenny Chang-Claude, Katja Butterbach, Andrea Gsur, Elaine C Johnstone
2019-03-21

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

Anna Lepistö, Esa Pitkänen, Toni T Seppälä, Netta Mäkinen, Jukka-Pekka Mecklin, Ulrika A Hänninen, E-V Wirta, Kimmo Palin, Lauri Aaltonen, Laura Renkonen-Sinisalo
2019-09-06

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

Päivi Sulo, Ulrika A Hänninen, Mervi Aavikko, Ari Ristimäki, Selja Koskensalo, Anna Lepistö, Toni T Seppälä, Jukka-Pekka Mecklin, Kimmo Palin, Lauri Aaltonen, Laura Renkonen-Sinisalo
2018-09-10

Contribution of allelic imbalance to colorectal cancer

Kimmo Palin, Esa Pitkänen, Biswajyoti Sahu, Teemu Kivioja, Tatiana Cajuso, Bernhard Schmierer, Sandeep K Botla, Maria Sokolova, Anna Vähärautio, Halit Ongen, Emmanouil Dermitzakis, Claus Lindbjerg Andersen, Anna Lepistö, Jukka-Pekka Mecklin, Ulrika A Hänninen, Lauri Aaltonen, Laura Renkonen-Sinisalo
2018-09-01

Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer

Kari Salokas, Xiaonan Liu, Tatiana Cajuso, Jussi Taipale, Anna Lepistö, Jukka-Pekka Mecklin, Halit Ongen, Sampsa Hautaniemi, Auli Karhu, Markku Varjosalo, Esa Pitkänen, Lauri Aaltonen, Ulrika A Hänninen, Laura Renkonen-Sinisalo
2018-09-18

Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

Niko Välimäki, Annukka Pasanen, Jaana Tolvanen, Amjad Alkodsi, Rainer Lehtonen, Kimmo Palin, Lauri Aaltonen
2018-03-09

Exome-wide somatic mutation characterization of small bowel adenocarcinoma

Kimmo Palin, Ulrika A Hänninen, Riku Katainen, Jukka-Pekka Mecklin, Esa Pitkänen, Netta Mäkinen, Lauri Aaltonen
2017-08-19

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Amit Sud, David Kerr, Richard Houlston, Kimmo Palin, Anna Lepistö, Aung Ko Win, Veikko Salomaa, Eero Pukkala, Claire Palles, John Hopper, Malcolm G. Dunlop, Aarno Palotie, Steven Garcia, Polly A Newcomb, David E. Fisher, Sebastian May-Wilson, Tatiana Cajuso, Ulrika A Hänninen, Philip J. Law, Maria Timofeeva, Salma M Wakil, Rachel S Kerr, Ian Tomlinson, Johan G. Eriksson, David V Conti, Noralane Lindor, Susan M Farrington, Jeremy P Cheadle, Daniel D Buchanan, Mark Jenkins, Lauri Aaltonen, Harry Campbell, Nada Al Tassan, Brian F Meyer, Shelley Idziaszczyk, Timothy S Maughan, Sari Tuupanen, Alexandra E Gylfe, Tomas Tanskanen, Johanna Kondelin, Antti-Pekka Sarin, Harri Rissanen, Paul Knekt, Pekka Jousilahti, Michael Passarelli, Jane C Figueiredo
2017-03-24

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Graham Casey, Veikko Salomaa, Samuli Ripatti, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Amit Sud, David Kerr, Kimmo Palin, Anna Lepistö, Aung Ko Win, Richard Houlston, Eero Pukkala, Claire Palles, John Hopper, Malcolm G. Dunlop, Aarno Palotie, Steven Garcia, Polly A Newcomb, Ian Tomlinson, Johan G. Eriksson, David V Conti, Noralane Lindor, Susan M Farrington, Jeremy P Cheadle, Salma M Wakil, Richard S Kaplan, Rachel S Kerr, Daniel D Buchanan, Mark Jenkins, Lauri Aaltonen, Ella Barclay, Harry Campbell, Nada Al Tassan, Brian F Meyer, Shelley Idziaszczyk, Timothy S Maughan, Maria Timofeeva, Sari Tuupanen, Alexandra E Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Antti-Pekka Sarin, Harri Rissanen, Paul Knekt, Pekka Jousilahti, Michael Passarelli, Jane C Figueiredo
2017-09-28

Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

Aung Ko Win, David Kerr, Richard Houlston, Anna Lepistö, Andres Metspalu, Veikko Salomaa, Eero Pukkala, Claire Palles, Kristian Hveem, John Hopper, Malcolm G. Dunlop, Fredrick Schumacher, Aarno Palotie, Kaisa Silander, Jukka-Pekka Mecklin, Polly A Newcomb, Tatiana Cajuso, Ulrika A Hänninen, Philip J. Law, Kimmo Palin, Maria Timofeeva, Salma M Wakil, Rachel S Kerr, Daniel D Buchanan, Mark Jenkins, Lauri Aaltonen, Laura Renkonen-Sinisalo, Heikki Järvinen, Ian Tomlinson, David V Conti, Susan M Farrington, Jeremy P Cheadle, Richard S Kaplan, Ella Barclay, Harry Campbell, Steve Gallinger, Nada Al Tassan, Brian F Meyer, Shelley Idziaszczyk, Sari Tuupanen, Alexandra E Gylfe, Tomas Tanskanen, Johanna Kondelin, Antti-Pekka Sarin, Pekka Jousilahti, Giulia Orlando, Mervi Aavikko, Tim S Maughan
2016-06-23

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

Jaakko Kaprio, Samuli Ripatti, Laura Renkonen-Sinisalo, David Kerr, Kimmo Palin, Anna Lepistö, Aung Ko Win, Malcolm G. Dunlop, Richard Houlston, Johan G. Eriksson, Veikko Salomaa, Eero Pukkala, Claire Palles, John Hopper, Aarno Palotie, Polly A Newcomb, David Jarvis, Tatiana Cajuso, Ulrika A Hänninen, Philip J. Law, Maria Timofeeva, Salma M Wakil, Rachel S Kerr, Daniel D Buchanan, Mark Jenkins, Lauri Aaltonen, Ian Tomlinson, David V Conti, Noralane Lindor, Susan M Farrington, Jeremy P Cheadle, Richard S Kaplan, Ella Barclay, Harry Campbell, Steve Gallinger, Nada Al Tassan, Brian F Meyer, Shelley Idziaszczyk, Timothy S Maughan, Sari Tuupanen, Alexandra E Gylfe, Tomas Tanskanen, Johanna Kondelin, Antti-Pekka Sarin, Harri Rissanen, Paul Knekt, Pekka Jousilahti
2016-03-22

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

Jaakko Kaprio, Malcolm G. Dunlop, Richard Houlston, Samuli Ripatti, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, David Kerr, Kimmo Palin, Anna Lepistö, Aung Ko Win, Veikko Salomaa, Eero Pukkala, Claire Palles, John Hopper, Aarno Palotie, Polly A Newcomb, Heikki Järvinen, Ian Tomlinson, Johan G. Eriksson, David V Conti, Noralane Lindor, Susan M Farrington, Jeremy P Cheadle, Salma M Wakil, Richard S Kaplan, Rachel S Kerr, Daniel D Buchanan, Mark Jenkins, Lauri Aaltonen, Ella Barclay, Harry Campbell, Steve Gallinger, Nada Al Tassan, Brian F Meyer, Shelley Idziaszczyk, Timothy S Maughan, Maria Timofeeva, Sari Tuupanen, Alexandra E Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Antti-Pekka Sarin, Harri Rissanen, Paul Knekt, Pekka Jousilahti, Giulia Orlando
2014-12-01

New target genes in endometrial tumors show a role for the estrogen-receptor pathway in microsatellite-unstable cancers

Carla Oliveira, Lauri Aaltonen, Ana M. Ferreira, Raquel Seruca, Robert Hofstra
2014-12-31

Systematic search for rare variants in Finnish early-onset colorectal cancer patients

Lauri Aaltonen, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Kimmo Palin, Heikki Järvinen
2014-03-18

Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas

Lauri Aaltonen, Netta Mäkinen, Hanna-Riikka Heinonen
2014-04-18

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity

Lauri Aaltonen, Mikko Turunen, Salla Keskitalo, Netta Mäkinen, Kimmo Palin, Anna Vähärautio, Markku Varjosalo
2014-08-12

Identification of 33 candidate oncogenes by screening for base-specific mutations

Lauri Aaltonen, Tatiana Cajuso, Jukka-Pekka Mecklin, Claus Lindbjerg Andersen, Kaisa Lehti, Esa Pitkänen, Hannele Yki-Järvinen, Minna Taipale
2014-12-01

High frequency of RPL22 mutations in microsatellite-unstable colorectal and endometrial tumors

Lauri Aaltonen, Ana M. Ferreira, Robert Hofstra
2014-07-29

Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome

Lauri Aaltonen, Elisa Rahikkala, Kimmo Palin, Jukka S Moilanen, Auli Karhu
2014-08-06

MED12 mutation frequency in unselected sporadic uterine leiomyomas

Lauri Aaltonen, Hanna-Riikka Heinonen, Esa Pitkänen, Netta Mäkinen
2014-10-13

Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry

Petrus Järvinen, Rainer Lehtonen, Anna Lepistö, Sampsa Hautaniemi, Lauri Aaltonen
2013-01-24

Nationwide registry-based analysis of cancer clustering detects strong familial occurrence of Kaposi sarcoma

Lauri Aaltonen, Rainer Lehtonen, Eero Pukkala
2013-10-17

Eleven candidate susceptibility genes for common familial colorectal cancer

Lauri Aaltonen, Tatiana Cajuso, Jukka-Pekka Mecklin, Esa Pitkänen, Auli Karhu, Laura Renkonen-Sinisalo, Heikki Järvinen, Minna Taipale
2013-02-27

MED12 exon 2 mutations in histopathological uterine leiomyoma variants

Lauri Aaltonen, Netta Mäkinen
2013-02-08

Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps

Lauri Aaltonen, Charis Eng, Rainer Lehtonen
2013-05-16

Identification of candidate oncogenes in human colorectal cancers with microsatellite instability

Ville Rantanen, Lauri Aaltonen, Mikko Turunen, Minna Taipale, Kimmo Palin, Markku Varjosalo, Jukka-Pekka Mecklin, Laura Renkonen-Sinisalo, Heikki Järvinen
2013-01-04

HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk

Liisa Pelttari, Anne Kallioniemi, Heli Nevanlinna, Lauri Aaltonen, Tapio Visakorpi, Anssi Auvinen, Johanna Schleutker, Robert L Vessella
2013-03-01

Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene.

Lauri Aaltonen, Sirpa Leppä

Human - wd:Q23039716

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