Joseph L. Goldstein

1940 -

Joseph Leonard Goldstein ForMemRS (born April 18, 1940) is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies regarding cholesterol. They discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Their studies led to the development of statin drugs. Source: Wikipedia (en)

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Articles 442

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2020-07-20

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Michael N Trinh, Michael Stuart Brown, Joseph L. Goldstein, Jaeil Han, Joachim Seemann, Joshua T Mendell, Feiran Lu
2019-03-25

Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice

Joseph L. Goldstein
2018-06-27

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

Xiang Chen, Zhijian J Chen, Joseph L. Goldstein
2018-07-26

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Michael N Trinh, Joseph L. Goldstein, Feiran Lu
2017-08-23

Artists Create Puzzles, Scientists Solve Them.

Joseph L. Goldstein
2017-04-03

Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis.

Arun Radhakrishnan, Joseph L. Goldstein
2017-08-25

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Joseph L. Goldstein
2016-09-03

The Rule of Three for Prizes in Science and the Bold Triptychs of Francis Bacon.

Joseph L. Goldstein
2016-04-11

Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS.

Nick Grishin, Joseph L. Goldstein
2016-07-05

Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex

Joseph L. Goldstein
2015-09-01

A Well-Hung Horse: Sired by Knowledge and Imagination

Joseph L. Goldstein
2015-01-12

Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone

Joseph L. Goldstein
2015-12-08

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Feiran Lu, Joseph L. Goldstein
2014-06-11

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

Joseph L. Goldstein
2014-10-01

Balzac's Unknown Masterpiece: spotting the next big thing in art and science

Joseph L. Goldstein
2014-05-15

Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet

Joseph L. Goldstein
2013-10-01

Juxtapositions in Trafalgar Square: tip-offs to creativity in art and science

Joseph L. Goldstein
2013-03-01

Why is it so hard to pay attention, or is it? Mindfulness, the factors of awakening and reward-based learning

Joseph L. Goldstein
2013-04-05

Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi

Joseph L. Goldstein
2013-06-10

Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells

Joseph L. Goldstein
2012-08-27

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Joseph L. Goldstein
2012-05-14

Scientific side trips: six excursions from the beaten path

Joseph L. Goldstein
2012-04-03

Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids

Joseph L. Goldstein
2012-05-01

A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Interview by Ushma S. Neil and Howard A. Rockman

Joseph L. Goldstein
2012-06-01

The ghrelin-growth hormone axis preserves gluconeogenesis to maintain blood glucose levels during starvation.

Joseph L. Goldstein
2012-06-01

Surviving starvation: essential role of the ghrelin-growth hormone axis.

Joseph L. Goldstein
2012-11-01

History of science. A golden era of Nobel laureates.

Joseph L. Goldstein
2012-10-01

Paradigm shifts in science: insights from the arts.

Joseph L. Goldstein
2012-02-01

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

Joseph L. Goldstein, Victor Koteliansky
2011-05-16

Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis

Joseph L. Goldstein
2011-03-24

Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis

Yinxin Zhang, Joseph L. Goldstein
2011-09-06

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice

Joseph L. Goldstein

Human - wd:Q271424

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