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A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog

Published in: Nature

Date of publication: November 9, 1995

Language: English

Main subject: crystal structure

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Cites articles 20

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Refined crystal structure of carboxypeptidase A at 1.54 A resolution
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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons
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Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
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Sonic hedgehog mediates the polarizing activity of the ZPA

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
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A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
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Alpha plus beta folds revisited: some favoured motifs

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Autoproteolysis in hedgehog protein biogenesis
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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
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Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine
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Hedgehog and beyond
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Developmental biology. Patterning goes sonic

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The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
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Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

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