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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Published in: Nature

Date of publication: October 3, 1996

Language: English

Bibliographic databases:

Cites articles 36

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Local signalling in dermomyotomal cell type specification
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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
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Sonic hedgehog mediates the polarizing activity of the ZPA

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A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
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Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
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Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

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Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
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Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

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A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog
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Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation

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