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How to improve R&D productivity: the pharmaceutical industry's grand challenge

published in: Nature Reviews Drug Discovery

date of publication: 2010-11-19

main subject: replication crisis, reproducibility

Cites articles 27

Date

Title

Authors

2009-06-16

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Yongmei Li
2008-12-16

Prescription drug spending trends in the United States: looking beyond the turning point
2008-02-01

The state of innovation in drug development
2008-11-19

PCSK9: a convertase that coordinates LDL catabolism

Helen Hobbs, Jay D Horton, Jonathan C. Cohen
2008-12-01

Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease
2008-05-01

Rebuilding the R&D engine in big pharma.
2008-12-01

Market watch : Pharma industry strategic performance: 2007-2012E.
2008-03-01

A more rational approach to new-product development
2007-02-20

Driving earlier clinical attrition: if you want to find the needle, burn down the haystack. Considerations for biomarker development
2007-02-01

The prospects for "personalized medicine" in drug development and drug therapy
2007-08-01

The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates
2007-12-01

Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders
2007-10-26

Sodium channels and nociception: recent concepts and therapeutic opportunities
2006-03-23

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
2006-06-01

Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to New Targets (TNT) study

Steven M. Haffner
2006-11

Drug discovery in jeopardy

Pedro Cuatrecasas
2005-01-01

Macro trends in pharmaceutical innovation.
2005-03-01

The impact of new drug launches on longevity: evidence from longitudinal, disease-level data from 52 countries, 1982-2001.
2005-01-25

Productivity in pharmaceutical-biotechnology R&D: the role of experience and alliances

Nuno Sousa Pereira
2005-02-01

Pricing medicines: theory and practice, challenges and opportunities
2004-05-01

Prospects for productivity
2004-08

Can the pharmaceutical industry reduce attrition rates?
2003-06

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

Jean Weissenbach, Corinne Cruaud, Jean-Pierre Rabès, Michel Krempf, Nabil Seidah, Mathilde Varret, Catherine Boileau, Ludovic Villéger, Marianne Abifadel, Delphine Allard, Claudine Junien, Khadija Ouguerram, Martine Devillers, Suzanne Benjannet, Louise Wickham, Danièle Erlich, Michel Farnier, Eric Bruckert
2002

The value of improving the productivity of the drug development process: faster times and better decisions,The Value of Improving the Productivity of the Drug Development Process
2002-09

The druggable genome
2001-01-01

Significance of the human genome sequence to drug discovery
1961-06

A Proof for the Queuing Formula:L= λW

Article - wd:Q28314992

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