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Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis

published in: Journal of Experimental Medicine

date of publication: 1998-02-01

language: English

main subject: endothelium, apoptotic process

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Cites articles 32

Date

Title

Authors

1991-10-01

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
1992-06-01

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
1992-12-11

Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes
1993-09-01

The extracellular matrix as a cell survival factor
1993-05-01

Mechanotransduction across the cell surface and through the cytoskeleton,Mechanotransduction Across the Cell Surface and Through the Cytoskeleton
1994-05-01

Anchorage dependence, integrins, and apoptosis
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Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression
1994-02

Disruption of epithelial cell-matrix interactions induces apoptosis
1994-10-01

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
1994-10-01

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1995

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995-06-01

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase
1995-02-01

Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.
1996-01-01

Focal adhesions, contractility, and signaling
1996-12-01

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis
1996-02-01

Assembly of focal adhesions: progress, paradigms, and portents
1996-08-01

Control of adhesion-dependent cell survival by focal adhesion kinase
1996-08-01

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases
1996-06-01

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling
1996-06-07

p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
1996-05-01

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death
1996-08-01

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain
1996-04-01

A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.
1997-07-18

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
1997-06-01

Temporal phases in apoptosis defined by the actions of Src homology 2 domains, ceramide, Bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction
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Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases
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Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
1997-05-30

Geometric control of cell life and death
1997-04-01

Substrate specificities of caspase family proteases

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