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Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

Published in: Nature

Date of publication: April 1, 1998

Language: English

Main subject: insertional mutagenesis, DNA sequencing

Bibliographic databases:

Cites articles 19

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Basic local alignment search tool

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Complementary DNA sequencing: expressed sequence tags and human genome project
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Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice
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Reverse genetics of Caenorhabditis elegans
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Hotspots and warm spots: integration specificity of retroelements
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Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells
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The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages
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Enrichment of insertional mutants following retrovirus gene trap selection
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Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice
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Distribution of targets for avian retrovirus DNA integration in vivo
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Gene disruptions using P transposable elements: an integral component of the Drosophila genome project
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Capturing genes encoding membrane and secreted proteins important for mouse development
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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
April 1, 1997

Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells
March 1, 1997

Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice
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Functional genomics in mice by tagged sequence mutagenesis
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Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains

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