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Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles

Author

Jonathan G Seidman

Published in: Proceedings of the National Academy of Sciences of the United States of America

Date of publication: August 1, 1991

Language: English

Main subject: gene targeting

Bibliographic databases:

Cites articles 30

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Adenylate cyclase assay
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Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system
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The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
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Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin
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Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains
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Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter
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Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium
April 1, 1987

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
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Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells
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The G protein-gated atrial K+ channel is stimulated by three distinct Gi alpha-subunits
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G protein multiplicity in eukaryotic signal transduction systems
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Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines
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Roles of G protein subunits in transmembrane signalling
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Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells
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Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
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Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells
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The G protein alpha o subunit alters morphology, growth kinetics, and phospholipid metabolism of somatic cells

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Polymorphisms in the coding and noncoding regions of murine Pgk-1 alleles

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