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Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes

Author

Randal J Kaufman

Published in: Proceedings of the National Academy of Sciences of the United States of America

Date of publication: November 1, 1979

Language: English

Main subject: methotrexate, extrachromosomal inheritance

Bibliographic databases:

Cites articles 29

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Double minute chromosomes are not centromeric regions of the host chromosomes
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Altered regulation of the rate of synthesis of dihydrofolate reductase in methotrexate-resistant hamster cells
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Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

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