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Is paradoxical pharmacology a strategy worth pursuing?

Published in: Trends in Pharmacological Sciences

Date of publication: June 1, 2001

Main subject: pharmacology

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Cites articles 17

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Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts,Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
January 1, 1982

Asthma and beta-blockers
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Elderly patients with schizophrenia exhibit infrequent neurodegenerative lesions
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Hyperresponsiveness of the airways following exposure of guinea-pigs to racemic mixtures and distomers of beta 2-selective sympathomimetics
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Adverse effects of alpha 1-adrenergic blocking drugs
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Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators
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Anti-hyperactivity medication: methylphenidate and amphetamine
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Dopamine D2 receptor bands in normal human temporal cortex are absent in Alzheimer's disease
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Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia,Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients With Schizophrenia
June 12, 1999

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)
March 1, 1999

Neurobiological correlates of a putative risk allele for Alzheimer's disease on chromosome 12q.
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In-vivo demonstration of dopaminergic degeneration in dementia with Lewy bodies
January 1, 1999

Beta-blockers after myocardial infarction: do benefits ever outweigh risks in asthma?
March 1, 2000

Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group

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Ischaemic preconditioning of the vasculature: an overlooked phenomenon for protecting the heart?
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Beta-blocker therapy for heart failure: the evidence is in, now the work begins
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Rational use of inotropic therapy in heart failure

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