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Development of hyperactive sleeping beauty transposon vectors by mutational analysis

Author

Hatem Zayed

Zsuzsanna Izsvák

1961 -

Published in: Molecular Therapy

Date of publication: February 1, 2004

Main subject: Sleeping Beauty transposon system

Bibliographic databases:

Cites articles 39

Date

Title

Authors

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Insertional mutagenesis of the Drosophila genome with single P elements
February 1, 1992

Characterization of two hypertransposing Tn5 mutants
October 1, 1994

The mechanism of transposition of Tc3 in C. elegans

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Evidence that the cis preference of the Tn5 transposase is caused by nonproductive multimerization.
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A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif
January 1, 1995

Horizontal transmission, vertical inactivation, and stochastic loss of mariner-like transposable elements
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Diverse transposable elements are mobilized in hybrid dysgenesis in Drosophila virilis
May 1, 1995

Characterization of a Tc1-like transposable element in zebrafish (Danio rerio).
September 1, 1995

Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases
May 14, 1996

Identification of functional domains and evolution of Tc1-like transposable elements
March 1, 1996

Transposase is the only nematode protein required for in vitro transposition of Tc1
April 1, 1996

Autoregulation of mariner transposase activity by overproduction and dominant-negative complementation.
September 1, 1997

Gene therapy -- promises, problems and prospects
November 14, 1997

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
May 1, 1997

What restricts the activity of mariner-like transposable elements.
August 1, 1997

Tn 5 transposase mutants that alter DNA binding specificity 1 1Edited by G. Smith
February 1, 1997

Mutations in the mariner transposase: the D,D(35)E consensus sequence is nonfunctional
May 1, 1997

Factors responsible for target site selection in Tn10 transposition: a role for the DDE motif in target DNA capture
September 1, 1998

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells
March 1, 1998

Tn5 in vitro transposition
August 1, 1999

Resident aliens: the Tc1/mariner superfamily of transposable elements
September 1, 1999

Hyperactive transposase mutants of the Himar1 mariner transposon
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Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates
May 1, 2000

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system
July 1, 2000

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate
June 5, 2001

Regulated transposition of a fish transposon in the mouse germ line
June 1, 2001

Transposition and gene disruption in the male germline of the mouse
July 1, 2001

Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice

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May 1, 2001

Effects of insert size on transposition efficiency of the sleeping beauty transposon in mouse cells
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Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo
December 1, 2002

In vivo correction of murine tyrosinemia type I by DNA-mediated transposition

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May 1, 2002

Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon

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