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Hypermutagenic PCR involving all four transitions and a sizeable proportion of transversions.

Author

Jean-Pierre Vartanian

Published in: Nucleic Acids Research

Date of publication: July 1, 1996

Language: English

Bibliographic databases:

Cites articles 25

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The infidelity of avian myeloblastosis virus deoxyribonucleic acid polymerase in polynucleotide replication
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On the enzymatic basis for mutagenesis by manganese
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On the fidelity of DNA replication: manganese mutagenesis in vitro
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Next-nucleotide effects in mutations driven by DNA precursor pool imbalances at the aprt locus of Chinese hamster ovary cells
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DNA mismatch correction
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The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells
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Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations
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Effects of primer-template mismatches on the polymerase chain reaction: human immunodeficiency virus type 1 model studies
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Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis,Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis
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Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes
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Modulation of mutagenesis by deoxyribonucleotide levels,Modulation of Mutagenesis by Deoxyribonucleotide Levels
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DNA precursor asymmetries, replication fidelity, and variable genome evolution
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Randomization of genes by PCR mutagenesis
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Extension of base mispairs by Taq DNA polymerase: implications for single nucleotide discrimination in PCR
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Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide
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Rates of spontaneous mutation among RNA viruses
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Polymerase chain reaction-based random mutagenesis: production and characterization of thermostable mutants of Zymomonas mobilis alcohol dehydrogenase-2.
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Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations
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G-->A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription
February 1, 1994

Loss of conserved cysteine residues in the attachment (G) glycoprotein of two human respiratory syncytial virus escape mutants that contain multiple A-G substitutions (hypermutations).
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Direct random mutagenesis of gene-sized DNA fragments using polymerase chain reaction
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Fate of direct and inverted repeats in the RNA hypermutagenesis reaction
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An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues

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