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Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea

Published in: Molecular and Cellular Biology

Date of publication: June 1, 1983

Language: English

Main subject: methotrexate, hydroxycarbamide

Bibliographic databases:

Cites articles 44

Date

Title

Authors

November 1943

Mutations of Bacteria from Virus Sensitivity to Virus Resistance
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Nutritional and amethopterin-resistant characteristics of leukemic clones
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Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells
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INDUCTION OF REPLICATION BY THYMINE STARVATION AT THE CHROMOSOME ORIGIN IN ESCHERICHIA COLI
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On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA
March 1, 1969

Replication of the bacterial chromosome: location of new initiation sites after irradiation
November 1, 1969

Degradation of DNA by carbamoyloxyurea--an oxidation product of hydroxyurea,Degradation of DNA by carbamoyloxyurea — An oxidation product of hydroxyurea
November 1, 1969

Initiation of DNA replication cycles in Escherichia coli following DNA synthesis inhibition
March 1, 1971

Effects of hydroxyurea and 1-beta-D-arabinofuranosyl-cytosine on deoxyribonucleotide pools in mouse embryo cells,Effects of Hydroxyurea and 1-beta-D-Arabinofuranosyl-cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells
January 1, 1972

The mutagenicity to mammalian cells of pyrimidine nucleoside analogs
January 1, 1973

Chapter 7: Isolation of Mutants of Cultured Mammalian Cells
January 1, 1975

Hydroxyurea.
January 1, 1976

On the nature of hereditable variation in cultured somatic cells
May 1, 1976

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells
March 1, 1977

Survival of CHO cells that replicated DNA in the presence of hydroxyurea*1,Survival of CHO cells that replicated DNA in the presence of hydroxyurea
November 1, 1978

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

,
December 1, 1978

Gene amplification and drug resistance in cultured murine cells
March 1, 1978

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells
November 1, 1979

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure
November 1, 1979

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells
September 1, 1979

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells
July 1, 1979

New developments on the mechanisms of action of antineoplastic drugs
June 1, 1979

Mouse albumin mRNA in liver and a hepatoma cell line. Preparation of complementary DNA from purified mRNA and quantitation by nucleic acid hybridization
October 1, 1979

Aberrant double replication of segments of chromosomal DNA following DNA synthesis inhibition by cytosine arabinoside
February 1, 1980

Structure and genomic organization of the mouse dihydrofolate reductase gene
June 1, 1980

Molecular cloning of DNA complementary to a mouse alpha-fetoprotein mRNA sequence
July 1, 1980

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases
June 1981

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells
April 1, 1981

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells
December 1, 1981

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines
October 1, 1981

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene

,
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Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion,Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

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