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Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

Author

Oliver Smithies

1925 - 2017

Published in: Molecular and Cellular Biology

Date of publication: March 1, 1991

Language: English

Bibliographic databases:

Cites articles 27

Date

Title

Authors

March 1, 1925

The Effects of Unequal Crossing over at the Bar Locus in Drosophila
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Chromosomal rearrangements and the evolution of haptoglobin genes,Chromosomal Rearrangements and the Evolution of Haptoglobin Genes
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Replacement of chromosome segments with altered DNA sequences constructed in vitro
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January 1, 1981

Metabolic cooperation between cells,Metabolic Cooperation between Cells
November 1, 1983

Evidence for intrachromosomal gene conversion in cultured mouse cells
January 1, 1984

Homologous recombination between repeated chromosomal sequences in mouse cells
June 1985

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
September 1985

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

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February 1, 1986

High frequency targeting of genes to specific sites in the mammalian genome
November 1, 1986

Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation

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January 1, 1987

Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells
November 6, 1987

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
December 1, 1987

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells
November 24, 1988

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
November 1988

Targeted mutation of the Hprt gene in mouse embryonic stem cells
December 1, 1988

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
December 15, 1988

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
November 1, 1988

Homologous integration in mammalian cells without target gene selection
December 1, 1989

High-frequency homologous recombination between duplicate chromosomal immunoglobulin mu heavy-chain constant regions
March 1, 1989

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells
March 1, 1989

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination
January 1, 1989

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells
June 1, 1990

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells

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June 1, 1990

Introduction of specific point mutations into RNA polymerase II by gene targeting in mouse embryonic stem cells: evidence for a DNA mismatch repair mechanism
May 1, 1990

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
March 19, 2017

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

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