Alan R. Clarke

1963 - 2015

country of citizenship: United Kingdom

languages spoken, written or signed: English

educated at: University of Bristol, University of Cambridge

occupation: researcher

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Articles 113

Date

Title

Authors

2018-05-16

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation

Toby J Phesse, Gareth-Rhys Jones, Peter C Cook, Michael Stürzl, Nathalie Britzen-Laurent, Owen J Sansom, Imran Ahmad, Adrian Peter Bird, Lee Parry, Alan R. Clarke
2015-08-03

E-cadherin can limit the transforming properties of activating β-catenin mutations

Lee Parry, David J Huels, Sujata Biswas, Karen R. Reed, Stefano Serra, Ola Söderberg, Alan R. Clarke, Owen J Sansom, Rachel A Ridgway, Nick Barker, Valerie S Meniel, Sorina Radulescu, Guenievre Moreaux
2015-07-20

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Wei-Yu Lu, Thomas Bird, Tim J Kendall, Alexander Raven, Alan R. Clarke, Owen J Sansom, Stuart J Forbes, Alicia M Cole, Rachel A Ridgway, Trevor Hay, Thomas Jamieson
2015-02-18

RNA Interference Using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models

Alan R. Clarke, Tristan D Clemons, Nicole M Smith
2014-01-23

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.

Alan R. Clarke, Victoria Marsh Durban
2014-07

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine

Madeleine Young, Alan R. Clarke, Daniel Metzger
2014-10-06

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes

Alan R. Clarke, Man-Wook Hur
2014-10-27

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes

Madeleine Young, Owen J Sansom, Alan R. Clarke
2014-01-15

OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer

Alan R. Clarke, Abdul Rawoof
2013-11-01

Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner.

Madeleine Young, Thierry Jarde, Alan R. Clarke
2013-06-01

PTEN loss and KRAS activation cooperate in murine biliary tract malignancies

Alan R. Clarke
2013-08-01

Cited1 deficiency suppresses intestinal tumorigenesis

Toby J Phesse, Madeleine Young, Sally L. Dunwoodie, Alan R. Clarke
2013-02-20

What are the best routes to effectively model human colorectal cancer?

Alan R. Clarke, Madeleine Young
2013-11-06

Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer

Alan R. Clarke, Victoria Marsh Durban, Marnix Jansen
2013-09-16

Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency

Alan R. Clarke
2013-08-31

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

Mark Pritchard, Alan R. Clarke, Karen R. Reed
2012-09-06

Conditional disruption of Axin1 leads to development of liver tumors in mice.

Thierry Jarde, Karen R. Reed, Alan R. Clarke, Trevor Dale
2012-01-01

Controlling the stem cell compartment and regeneration in vivo: the role of pluripotency pathways

Alan R. Clarke
2011-02-08

Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB

Karen R. Reed, Alan R. Clarke
2011-07-15

Expanding the p53 toolkit: a new platform for rapid engineering of the p53 locus in vivo.

Madeleine Young, Alan R. Clarke
2011-01-19

Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder

Alan R. Clarke
2011-12-03

Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice

Madeleine Young, Simon J. Tunster, Karen R. Reed, Rosalind John, Alan R. Clarke
2011-01-15

LKB1 loss of function studied in vivo

Alan R. Clarke
2011-04-01

Origin and maintenance of the intestinal cancer stem cell

Alan R. Clarke
2011-06-01

The Roles of the Methyl-CpG Binding Proteins in Cancer

Alan R. Clarke, Lee Parry
2011-06-03

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

Owen J Sansom, Alan R. Clarke
2011-11-14

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

Lee Parry, Alan R. Clarke, Paloma Ordóñez-Morán, Alexander Greenhough, Ann C Williams, John M Mariadason, Joerg Huelsken
2011-12-09

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis

Alan R. Clarke, Rhian S Thomas, Emma J Blain
2011-08-03

Intestinal renin-angiotensin system is stimulated after deletion of Lkb1.

Thierry Jarde, Alan R. Clarke, Alan Ashworth
2010-01-15

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

Dimitris Athineos, Michael S. Samuel, Helen Abud, Joan K. Heath, Matthias Ernst, Steven A Stacker, Inke Nathke, Alan R. Clarke, Owen J Sansom, Valerie S Meniel, Ian P. Newton, Joerg Huelsken
2010-11-01

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

Lee Parry, Alan R. Clarke, Owen J Sansom, Hans Clevers, Alicia M Cole, Rachel A Ridgway, Nick Barker
2010-08-24

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

Alan R. Clarke, Owen J Sansom, Dimitris Athineos, Karen R. Reed, Hans Clevers, Alicia M Cole, Rachel A Ridgway, Vanesa Muncan, Kevin B Myant

Human - wd:Q37382452

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