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Atherosclerosis: The low-density lipoprotein receptor hypothesis

Author

Joseph L. Goldstein

1940 -

Published in: Metabolism

Date of publication: November 1, 1977

Language: English

Main subject: atherosclerosis, lipoprotein, binding site, endocrinology

Bibliographic databases:

Cites articles 47

Date

Title

Authors

September 1, 1964

THE INHERITANCE OF ESSENTIAL FAMILIAL HYPERCHOLESTEROLEMIA
February 1, 1964

YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L
October 1, 1965

Cholesterol ester metabolism
February 1, 1965

SURFACE SPECIALIZATIONS OF ABSORBING CELLS
October 1, 1971

The distribution and composition of serum lipoproteins in eighteen animals
August 1, 1971

Coronary heart disease in seven countries
June 1, 1972

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia
July 1, 1973

Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia
October 1973

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol
July 1, 1974

Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man.
March 1974

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity
November 1, 1974

Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia
January 1, 1974

Cholesterol synthesis by cultured fibroblasts: decreased feedback inhibition in familial hypercholesterolemia
April 1, 1974

Cholesterol at birth and age 1: comparison of normal and hypercholesterolemic neonates
April 1, 1975

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts
February 1, 1975

Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism
May 1, 1975

Lipoprotein uptake by cultured human arterial smooth muscle cells
November 1, 1975

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts
March 1, 1975

The metabolism of the apoprotein of plasma low density lipoprotein in familial hype rbetalipoproteinaemia in the homozygous form,The metabolism of the apoprotein of plasma low density lipoprotein in familial hyperbetalipoproteinaemia in the homozygous form
December 1975

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia

,
September 1, 1975

Coronary heart disease--the global picture,Coronary heart disease — The global picture
August 1, 1975

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein
January 1, 1975

Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations
March 1, 1975

Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor
April 1, 1975

Lipoprotein receptors, cholesterol metabolism, and atherosclerosis
January 1, 1975

Lipoproteins and lipid transport
November 1, 1975

Observations on the Passage of Apoproteins from Plasma Lipoproteins into Peripheral Lymph in Two Men
December 1, 1976

Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein
February 1, 1976

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and the esterification of cholesterol in human long term lymphoid cell lines
January 16, 1976

Receptor-mediated control of cholesterol metabolism
June 1, 1976

Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor

,
August 1, 1976

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia

Article -

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