James Murphy
country of citizenship: New Zealand
languages spoken, written or signed: New Zealand English
educated at: University of Canterbury, Australian National University
occupation: researcher
official website: www.wehi.edu.au/people/james-murphy
Articles 132
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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
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The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
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The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
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SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization
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Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance
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Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
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Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
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Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix
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Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases
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Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
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Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues
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MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
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Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
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A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
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Relating SMCHD1 structure to its function in epigenetic silencing
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Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
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Potent inhibition of Necroptosis by simultaneously targeting multiple effectors of the pathway
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BAK core dimers bind lipids and can be bridged by them
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Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice
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SMCHD1 is involved in de novo methylation of the DUX4-encoding D4Z4 macrosatellite
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The long-awaited structure of HIPK2
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Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3
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The PEAK family of pseudokinases, their role in cell signalling and cancer
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Activated MLKL attenuates autophagy following its translocation to intracellular membranes
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Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS
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Eph receptor signalling: from catalytic to non-catalytic functions
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Emerging concepts in pseudoenzyme classification, evolution, and signaling
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The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
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Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway
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The anticonvulsive Phenhydan® suppresses extrinsic cell death
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Long-range chromatin interactions on the inactive X and at Hox clusters are regulated by the non-canonical SMC protein Smchd1
Human - wd:Q39048967