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Salmeterol‐induced desensitization, internalization and phosphorylation of the human β2‐adrenoceptor

Published in: British Journal of Pharmacology

Date of publication: February 1, 1998

Language: English

Main subject: phosphorylation, desensitization, beta2-adrenergic agonist

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Cites articles 24

Date

Title

Authors

December 1, 1983

Determination of the desensitization of β-adrenergic receptors by [3H]CGP-12177
October 1, 1984

Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo,Translocation and Uncoupling of theβ-Adrenergic Receptor in Rat Lung after Catecholamine Promoted Desensitizationin Vivo
March 1, 1986

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase
January 1, 1986

Desensitization of hormonal stimuli coupled to regulation of cyclic AMP levels
March 1, 1988

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells
November 1, 1991

Salmeterol, a novel, long-acting β2-adrenoceptor agonist: characterization of pharmacological activity in vitro and in vivo
October 1, 1991

G-protein-coupled receptor kinases.
October 1, 1992

Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma
October 1, 1992

Equilibrium and kinetic studies of the interactions of salmeterol with membrane bilayers
January 1, 1993

Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator
January 1, 1993

The pharmacology of salmeterol.
October 1, 1993

Salmeterol, a long-acting beta 2-adrenoceptor agonist mediating cyclic AMP accumulation in a neuronal cell line
February 1, 1993

Investigations into factors determining the duration of action of the beta 2-adrenoceptor agonist, salmeterol
October 1, 1994

Comparison of salmeterol with placebo in mild asthma: effect on peripheral blood phagocyte function and cytokine levels
May 1, 1994

Sequestration of muscarinic cholinergic receptors in permeabilized neuroblastoma cells
September 1, 1995

Beta-adrenergic receptors and their regulation
November 1, 1995

Rapid onset of tolerance to the bronchoprotective effect of salmeterol,Rapid Onset of Tolerance to the Bronchoprotective Effect of Salmeterol
November 1, 1995

Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle
March 1, 1996

Extent of salmeterol-mediated reassertion of relaxation in guinea-pig trachea pretreated with aliphatic side chain structural analogues
January 1, 1996

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
October 1, 1996

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor
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Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor
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Relaxation kinetics of formoterol and salmeterol in the guinea pig trachea in vitro

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beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists,β2-Adrenergic Receptor Desensitization, Internalization, and Phosphorylation in Response to Full and Partial Agonists

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