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Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation

Published in: The EMBO Journal

Date of publication: July 1, 1987

Language: English

Main subject: Adenoviridae, mutational analysis

Cites articles 48

Date

Title

Authors

January 1, 1977

Transformation with specific fragments of adenovirus DNAs. I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA,Transformation with specific fragments of adenovirus DNAs I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA
July 1, 1978

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

,
May 1, 1978

Defective transforming capacity of adenovirus type 5 host-range mutants
July 1978

Structure of the adenovirus 2 early mRNAs
October 1, 1979

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses
July 1, 1979

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells
October 25, 1979

Complex splicing patterns of RNAs from the early regions of adenovirus-2
September 1, 1980

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.
November 1, 1980

Construction and characterization of new coliphage M13 cloning vectors
February 1, 1980

The structure of adenovirus 2 early nuclear and cytoplasmic RNAs
December 1, 1980

Comparison of nucleotide sequences of the early E1a regions for subgroups A, B and C of human adenoviruses
December 1, 1981

Transformation-defective mutant of adenovirus type 5 containing a single altered E1a mRNA species
August 1, 1981

Alterations to controls of cellular DNA synthesis by adenovirus infection
January 1, 1981

Cloning of a DNA fragment from the left-hand terminus of the adenovirus type 2 genome and its use in site-directed mutagenesis
October 1, 1981

Mechanism of activation of early viral transcription by the adenovirus E1A gene product
1982

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter
May 1982

Isolation of a transforming sequence from a human bladder carcinoma cell line
July 1, 1982

Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product
July 1, 1983

E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes
November 1, 1983

Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection
December 1, 1983

The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related
December 1, 1983

Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit
August 18, 1983

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
August 1, 1983

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
July 1, 1983

Adenovirus 2 Ip+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation
January 1, 1983

Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors,32 Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors
December 1, 1984

HeLa cell beta-tubulin gene transcription is stimulated by adenovirus 5 in parallel with viral early genes by an E1a-dependent mechanism
August 1, 1984

Dissection of overlapping functions within the adenovirus type 5 E1A gene
September 1, 1984

Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products
April 1, 1984

Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes
December 13, 1984

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription
March 1, 1985

An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested human cells

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