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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

Published in: Journal of Experimental Medicine

Date of publication: April 1, 1993

Language: English

Bibliographic databases:

Cites articles 28

Date

Title

Authors

April 1, 1981

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis
October 1, 1984

Response of resting human peripheral blood natural killer cells to interleukin 2.
June 1, 1985

Mutant EL-4 thymoma cells polyclonally activate murine and human B cells via direct cell interaction
January 1, 1985

A leukocyte subset bearing HLA-DR antigens is responsible for in vitro alpha interferon production in response to viruses
January 1, 1988

Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells

,
November 1, 1988

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells
July 1, 1988

Profiles of lymphokine activities and helper function for IgE in human T cell clones
1989

Biology of natural killer cells
January 1, 1989

Heterogeneity of cytokine secretion patterns and functions of helper T cells
September 1, 1989

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
March 1, 1990

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells
June 1, 1990

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients
November 1, 1991

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis
September 1, 1991

Selection of a human T helper type 1-like T cell subset by mycobacteria
July 1, 1991

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
May 1, 1991

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production

,
November 1, 1991

Functional subsets of allergen-reactive human CD4+ T cells
May 15, 1991

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
May 1, 1991

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
April 1, 1991

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers
April 1, 1992

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones
October 1, 1992

Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?
December 1, 1992

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells
November 1, 1992

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
March 1, 1992

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients
October 1, 1992

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice
February 1, 1992

IL-4 induces a Th2 response in Leishmania major-infected mice
November 1, 1992

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones

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