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The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization

author

Charles Antzelevitch

2000 -

Arthur Wilde

1956 -

published in: Journal of Molecular and Cellular Cardiology

date of publication: 2010-07-24

main subject: pathophysiology, Brugada syndrome

Cites articles 78

Date

Title

Authors

2010-02-01

Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation

Jan A Kors, Arthur Wilde, Gerard van Herpen
2009-09-29

SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome

Jean-Jacques Schott, Hervé Le Marec, Solena Le Scouarnec, Julien Barc, Juliette Albuisson, Florence Kyndt, Jean-Jacques Schott, Vincent Probst, Pascale Guicheney, Arthur Wilde, Laetitia Gouas, Frederic Sacher, Philippe Mabo
2009-10-12

Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch

Mark Potse, Ruben Coronel, Andrel Linnenbank, Arie O. Verkerk, Hester den Ruijter, Arthur Wilde
2009-12-01

Ventricular late potential in patients with apparently normal electrocardiogram; predictor of Brugada syndrome
2009-07-08

Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)

Josep Brugada, Martin Borggrefe, Christian Wolpert, Arthur Wilde, Dan Roden, Vincent Probst, Hanno Tan, Pieter G Postema, Silvia Priori
2009-08-24

Exercise-induced ECG changes in Brugada syndrome.

Jan M Ruijter, Arthur Wilde
2009-01-31

Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome.
2008-08-01

Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome

Charles Antzelevitch, Eva Delpón, Lucía Nuñez, Jorgen K. Kanters
2008-12-10

A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome

Kirstine Calloe, Søren-Peter Olesen, Charles Antzelevitch
2008-10-06

Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome

Douglas P. Zipes
2008-05-02

Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression

Charles Antzelevitch
2008-05-02

Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation

Thomas O'Hara
2008-03-04

Repolarization heterogeneity in the right ventricular outflow tract: correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model

Douglas P. Zipes
2008-12-07

Absence of pathognomonic or inflammatory patterns in cardiac biopsies from patients with Brugada syndrome

Günter Breithardt, Lars Eckardt, Thomas Wichter
2008-12-02

Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study

Andrel Linnenbank, Ruben Coronel, Arthur Wilde
2008-11-23

Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases

Nathalie Gaborit, Stanley Nattel
2008-08-01

Fever increases the risk for cardiac arrest in the Brugada syndrome

Arthur Wilde
2007-11-21

Cellular mechanism and arrhythmogenic potential of T-wave alternans in the Brugada syndrome

Charles Antzelevitch
2007-10-04

Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome
2007-09-24

Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with brugada syndrome: multicenter study in Japan
2006-11-30

Syncope due to Brugada syndrome in a young athlete
2006-05-01

Sodium channel variants in heart disease: expanding horizons
2006-03-01

Spontaneous alternans in Brugada ECG morphology.

Arash Arya
2006-04-24

Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
2006-10-01

Brugada syndrome

Charles Antzelevitch
2006-06-09

Diagnostic value of flecainide testing in unmasking SCN5A-related Brugada syndrome

Jan M Ruijter, Arthur Wilde
2005-12-01

Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome

Tommaso Sanna, Carlo Napolitano, Maurizio Pieroni
2005-11-01

Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study

Ruben Coronel, Joris R de Groot, Arie O. Verkerk, Andrel Linnenbank, Arthur Wilde, Pedro Brugada
2005-10-01

Brugada syndrome and ischemia-induced ST-segment elevation. Similarities and differences

Charles Antzelevitch
2005-09-27

Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging

Flavien Charpentier, Denis Escande, William H. Colledge, Ronald Wilders, Jacques M T de Bakker
2005-08-01

Mechanisms of disease: current understanding and future challenges in Brugada syndrome
2005-08-01

Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?

Arthur Wilde

Article - wd:Q41772555

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