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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Published in: Nature

Date of publication: 2000-12-01

Language: limba engleză

Main subject: boala Alzheimer

Bibliographic databases:

Cites articles 14

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Inflammation and Alzheimer's disease pathogenesis
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Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice
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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat.
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The importance of inflammatory mechanisms in Alzheimer disease
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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
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Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.
1999-08-01

Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes
2000-08-01

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
2000-07-01

Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody.
2000-06-01

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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