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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

Author

Mario Rossi

Luisa Castagnoli

Gianni Cesareni

Published in: Journal of Biological Chemistry

Date of publication: July 6, 2000

Language: English

Bibliographic databases:

Cites articles 39

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Title

Authors

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
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T antigen is bound to a host protein in SV40-transformed cells,T antigen is bound to a host protein in SY40-transformed cells
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p53 mutations: gains or losses?
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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding
May 1, 1993

Gain of function mutations in p53
May 15, 1994

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
September 1, 1995

Induction of apoptosis in HeLa cells by trans-activation-deficient p53
October 10, 1995

A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution
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Ecdysone-inducible gene expression in mammalian cells and transgenic mice
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p53, the cellular gatekeeper for growth and division
February 1, 1997

p53; from inductive signal to cellular effect
August 22, 1997

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers,Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers
September 1, 1997

p73 is a simian [correction of human] p53-related protein that can induce apoptosis
September 1, 1997

Lonely no more: p53 finds its kin in a tumor suppressor haven,Lonely No More: p53 Finds Its Kin in a Tumor Suppressor Haven
April 1, 1998

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control
June 1, 1998

Mutant p53 protein expression interferes with p53-independent apoptotic pathways
July 1, 1998

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain,Activation of c-myc Gene Expression by Tumor-Derived p53 Mutants Requires a Discrete C-Terminal Domain
November 1, 1998

p73, a gene related to p53, is not mutated in esophageal carcinomas,p73, a geme related top53, is not mutated in esophageal carcinomas
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Viral oncoproteins discriminate between p53 and the p53 homolog p73.
December 1, 1998

The large T antigen of simian virus 40 binds and inactivates p53 but not p73.
November 1, 1998

Two new p73 splice variants, gamma and delta, with different transcriptional activity

, , ,
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Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs
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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

,
December 1, 1998

Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73
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Regulation of the p53 tumor suppressor protein
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The emerging p53 gene family
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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
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p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
April 22, 1999

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
April 22, 1999

p63 is a p53 homologue required for limb and epidermal morphogenesis

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