John A. Todd

1958 -

award received: Fellow of the Royal Society

official website: www.well.ox.ac.uk/people/john-todd

John Andrew Todd FMedSci FRS (born 23 June 1958) is Professor of Precision Medicine at the University of Oxford, director of the Wellcome Center for Human Genetics and the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, in addition to Jeffrey Cheah Fellow in Medicine at Brasenose College. He works in collaboration with David Clayton and Linda Wicker to examine the molecular basis of type 1 diabetes. Source: Wikipedia (en)

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Articles 210

Date

Title

Authors

2021-06-14

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

Catherine Robertson, Suna Onengut, Antony J Cutler, Robert P. Kimberly, Panos Deloukas, Jean M Lawrence, Carla J Greenbaum, Peter K Gregersen, Flemming Pociot, David B. Dunger, Linda S Wicker, John A. Todd, Stephen S Rich
2021-08-03

Using de novo assembly to identify structural variation of eight complex immune system gene regions

Hannah E Roberts, Antony J Cutler, Justin P Whalley, Olga Mielczarek, Craig Corton, Rachael Bashford-Rogers, Julian C Knight, John A. Todd, Gavin Band
2021-11-04

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

Damien J Downes, Peng Hua, Nigel A Roberts, Ron Schwessinger, Antony J Cutler, Jill M Brown, Julian C Knight, John A. Todd, Stephen N Sansom, Fadi Issa, James O. Davies, Jim R Hughes
2021-10-28

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

Edward Mountjoy, Jeremy Schwartzentruber, Eliseo Papa, Eric Fauman, John A. Todd, David Ochoa, Ian Dunham, Maya Ghoussaini
2020-07-14

CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

Rebeca Arroyo Hornero, Peng Hua, John A. Todd, Fadi Issa, Joanna Hester
2018-09-01

Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

David B. Dunger, John A. Todd, Anne Smith
2018-03-21

Frequent Monitoring of C-peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

David B. Dunger, John A. Todd, Anne Smith
2018-12

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

John A. Todd
2018-09-17

Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Marta Martínez-Bonet, Suna Onengut, Aaron R Quinlan, Soumya Raychaudhuri, Tom Huizinga, Lars Klareskog, John A. Todd, Peter K Gregersen, Nikola Teslovich, Jane Worthington, Peter A Nigrovic
2018-08-04

Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial

Paul Moayyedi, John A. Todd
2017-01-17

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

John J Lambourne, Ellen Schofield, Steven W Wingett, Willem H. Ouwehand, John A. Todd
2017-05-05

Cells With Treg-Specific FOXP3 Demethylation But Low CD25 Are Prevalent In Autoimmunity

David B. Dunger, John A. Todd
2017-05-02

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment

Joao Oliveira, Frank D Waldron-Lynch, John A. Todd
2017-05-05

Consequences Of Natural Perturbations In The Human Plasma Proteome

James Blackshaw, Karsten Suhre, Willem H. Ouwehand, John A. Todd, John Danesh, Caroline S Fox, Nicholas W Morrell
2017-08-01

Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study

Peter Bergsten, Tove Fall, Nicholas J. Cooper, Christoph Nowak, John A. Todd
2017-10-05

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial

Antony J Cutler, Neil M Walker, Jia Lu, Deborah Smyth, Linda S Wicker, Frank D Waldron-Lynch, Helen E Stevens, John A. Todd, Sarah L. Caddy, Kara M D Hunter, Marcin L Pekalski, Ben Challis, Jane Kennet
2017-08-17

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

Chris Wallace, Helen E Stevens, Deborah Smyth, David B. Dunger, John A. Todd, Linda S Wicker, Frank D Waldron-Lynch, Neil M Walker, Antony J Cutler, Daniel B Rainbow, Simon Duley, Marcin L Pekalski, Arcadio Rubio García, Xaquin Castro Dopico, Meghavi Mashar, Natalia Savinykh, Claire Shannon Lowe
2017-09-04

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Chris Wallace, John J Lambourne, Steven W Wingett, Oliver Burren, Willem H. Ouwehand, John A. Todd, Linda S Wicker, Antony J Cutler, Nicholas J. Cooper, Kate Downes, Daniel B Rainbow, Arcadio Rubio García, Xaquin Castro Dopico
2017-07-23

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Chris Wallace, Joao Oliveira, Deborah Smyth, David B. Dunger, John A. Todd, Linda S Wicker, Antony J Cutler, Daniel B Rainbow, Marcin L Pekalski, Xaquin Castro Dopico, Meghavi Mashar, Natalia Savinykh
2017-12-07

Allele-specific methylation of type 1 diabetes susceptibility genes.

John A. Todd
2017-10-05

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

Chris Wallace, Leonardo Bottolo, Neil M Walker, John A. Todd
2017-06-19

Fine-mapping identifies causal variants for RA and T1D in DNASE1L3, SIRPG, MEG3, TNFAIP3 and CD28/CTLA4 loci

Lars Klareskog, Peter K. Gregersen, John A. Todd, Tom Huizinga, Aaron R Quinlan, Nikola Teslovich, Jane Worthington, Peter A Nigrovic
2017-11-28

Targeting regulatory T cells with Interleukin-2 treatment in type 1 diabetes: a response-adaptive, non-randomised, open-label trial of repeat doses of Aldesleukin (DILfrequency)

Neil M Walker, Mark L. Evans, John A. Todd, Linda S Wicker, Frank D Waldron-Lynch, Linsey Porter, Jane Kennet, Katerina Anselmiova
2017-03-24

Type 1 diabetes genome-wide association analysis with imputation identifies five new risk regions

Nicholas J. Cooper, Neil M Walker, John A. Todd, Antony J Cutler
2017-02-14

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

Linda S Wicker, Oliver Burren, Antony J Cutler, Neil M Walker, Chris Wallace, John A. Todd, Daniel B Rainbow
2017-04-01

Overexpression of the Cytokine BAFF and Autoimmunity Risk

Alessandro P Delitala, Matteo Piga, Marta E Alarcón-Riquelme, Michaelbernard Whalen, Fausto Poddie, Davide Firinu, Maristella Steri, Matteo Floris, Berta Martins Silva, Patricia E Carreira, Eleonora Cocco, Ingrid Kockum, Edoardo Fiorillo, Valeria Orrù, Valeria Faà, Andrea Angius, Francesca Deidda, Sandra Lai, Antonio Gonzalez, Maurizio Leone, Michele Marongiu, Francesco Cucca, Lars Alfredsson, John A. Todd, Isadora Asunis, Mauro Pala, Gabriella Sole, Maristella Pitzalis, Andrea Maschio, Mara Marongiu, Maria Giovanna Danieli, Mauro Congia, Stephen Montgomery, Tomas Olsson, Stephen Sawcer, Nadia Barizzone, Franca Rosa Guerini, Izaura Lima Bomfim
2016-12-26

A method for identifying genetic heterogeneity within phenotypically defined disease subgroups

Chris Wallace, John A. Todd
2016-11-01

Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease.

John A. Todd
2016-08-30

Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

Charles D Murray, Nicholas A. Kennedy, Chris J Hawkey, Naila Arebi, John A. Todd, Jack Satsangi, Malcolm G. Dunlop, Cathryn Edwards, Catriona Keerie
2016-10-11

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

Marina Evangelou, Antony J Cutler, Neil M Walker, Deborah Smyth, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Helen Schuilenburg, James Heywood, Sankalpa Neupane, Katerina Anselmiova, Judy Brown, Sarah L. Caddy, Jia Lu, Ian Goodfellow, Chris Wallace, Timothy Tree, Mark L. Evans, Simon Bond, Frank D Waldron-Lynch, Helen E Stevens, Linda S Wicker, John A. Todd, Jennie H M Yang, Gillian Coleman, Daniel B Rainbow, Marcin L Pekalski, Pamela N Clarke, Linsey Porter, Ben Challis, Donna Goymer, Jane Kennet
2016-11-17

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

Luigi Grassi, Jonathan Cairns, Steven W Wingett, Biola M. Javierre, Mikhail Spivakov, Oliver Burren, Steven P Wilder, Daniel R Zerbino, Antony J Cutler, Peter Fraser, Oliver Stegle, Chris Wallace, Myrto Kostadima, Willem H. Ouwehand, John A. Todd, Hendrik Gerard Stunnenberg, Roman Kreuzhuber, Samantha Farrow, Kate Downes, Mattia Frontini
2016-10-26

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity

Mark Peakman, Chantal Mathieu, John A. Todd, Jill M. Norris, Gerald T Nepom

Human - wd:Q6217960

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