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Design of isoform-selective inhibitors of nitric oxide synthase

Published in: Current Opinion in Chemical Biology

Date of publication: August 1, 1998

Language: English

Main subject: drug design

Bibliographic databases:

Cites articles 71

Date

Title

Authors

December 1, 1973

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
September 1, 1987

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst
April 1, 1989

NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?
May 1989

Role of endothelium-derived nitric oxide in the regulation of blood pressure
May 1, 1990

Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin
November 1, 1990

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis
December 1, 1990

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells
April 1, 1990

Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide
July 1, 1990

Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine
January 1, 1991

Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells,Identification of N-iminoethyl-l-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells
March 1, 1992

NG-allyl- and NG-cyclopropyl-L-arginine: two novel inhibitors of macrophage nitric oxide synthase
January 1, 1992

L-canavanine selectively augments contraction in aortas from endotoxemic rats
August 1, 1993

Suppression of arthritis by an inhibitor of nitric oxide synthase
August 1, 1993

Nitric oxide and arthritis
March 1, 1993

Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats
December 1, 1993

Targeted disruption of the neuronal nitric oxide synthase gene.
August 1, 1993

Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine
February 1, 1993

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation
January 1, 1994

The arginine-nitric oxide pathway: a target for new drugs
May 1, 1994

Spin trapping of nitric oxide produced in vivo in septic-shock mice
June 1, 1994

The inhibition of the constitutive and inducible nitric oxide synthase isoforms by indazole agents
December 1, 1994

Characterization of the inactivation of nitric oxide synthase by NG-methyl-L-arginine: evidence for heme loss
November 1, 1994

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase
January 1, 1995

Nitric oxide in the regulation of blood flow and arterial pressure
January 1, 1995

Nitric oxide: pathophysiological mechanisms
January 1, 1995

Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition
January 1, 1995

Nitric oxide synthases: properties and catalytic mechanism
November 1, 1995

The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse
November 1, 1995

Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthase
May 1, 1995

S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo
June 1, 1995

N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases
January 1, 1995

Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase

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