The Principles and Practice of Medicine: Designed for the Use of Practitioners and Students of Medicine is a medical textbook by Sir William Osler. It was first published in 1892 by D. Appleton & Company, while Osler was professor of Medicine at Johns Hopkins University. The book established Osler as the world's leading authority in the teaching of modern medicine.The text was translated into French, German, Russian, Portuguese, Spanish and Chinese, and for over 40 years it was the world's most significant medical textbook. Source: Wikipedia (en)