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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Author

James K. Chen

Publicado em: Genes & Development

Date of publication: 1 de novembro de 2002

Language: inglês

Bibliographic databases:

Cites articles 31

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
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Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

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The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
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The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
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An LDL-receptor-related protein mediates Wnt signalling in mice
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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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Patched acts catalytically to suppress the activity of Smoothened
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Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation
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