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Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants

published in: PLOS One

date of publication: 2008-10-15

language: English

main subject: serotonin

Cites articles 50

Date

Title

Authors

2008-07-01

Mutations in human monoamine-related neurotransmitter pathway genes

Jan Haavik
2008-01-22

Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency

Jean-Martin Beaulieu, Raul Gainetdinov, Marc Caron
2008-01-11

Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
2008-07-30

Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice.

Klaus-Peter Lesch
2008-04-01

A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder.

Stefan Johansson, Ingeborg Winge, Jan Haavik
2008-02-15

Neurochemical responses to antidepressants in the prefrontal cortex of mice and their efficacy in preclinical models of anxiety-like and depression-like behavior: a comparative and correlational study
2007-06-01

Update on pharmacotherapy guidelines for treatment of neuropathic pain
2007-01-01

Use of the sustained pain-free plus no adverse events endpoint in clinical trials of triptans in acute migraine

David W Dodick
2006-12-20

Maternal serotonin is crucial for murine embryonic development
2006-07-01

Clinical potential of milnacipran, a serotonin and norepinephrine reuptake inhibitor, in pain
2006-04-11

No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects

Catalina Betancur, Thomas Bourgeron, Gilles Bertschy, Fabrice Jollant, Richard Delorme, Christopher Gillberg, Marion Leboyer, Michael Wagner
2006-04-01

Is serotonin hyperalgesic or analgesic?
2006-11-22

No association between TPH2 gene polymorphisms and ADHD in a UK sample.

Ziarih Hawi, Michael Gill, Lindsey Kent
2006-07-25

A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants.
2006-03-20

Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice.
2005-10-01

Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD

Michael Gill, Ziarih Hawi
2005-07-01

The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments

Francesco Benedetti, Alessandro Serretti, Enrico Smeraldi, Raffaella Zanardi
2005-07-01

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

Rita J. Valentino, John F. Cryan
2005-05-01

Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2)

Hilary Coon
2005-09-22

Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying
2005-11-01

A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests

Nadège Ripoll, Michel Bourin, Denis Joseph Paul David
2004-10-01

Testing of analgesic effect of fluoxetine
2004-02-20

S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole

Trevor Sharp, Mariusz Papp
2003-11-03

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function

Etienne A Thévenot, Yves Fromes, Michele Darmon
2003-11-01

A unique central tryptophan hydroxylase isoform

Michael Bader
2003-01-03

Synthesis of serotonin by a second tryptophan hydroxylase isoform

Michael Bader
2003-03-01

Knockout mouse points to second form of tryptophan hydroxylase

Jeremy Veenstra-VanderWeele, Edwin H Cook
2003-01-01

Serotonin and its implication for the management of irritable bowel syndrome
2003-11-01

Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice

Victoria Arango, Nathalie Castanon, Mark D Underwood, René Hen
2003-08-01

Monoamine metabolism changes following the mouse forced swimming test but not the tail suspension test

Denis J David, Michel Bourin, Eric Dailly, Martine Hascoët
2002-07-19

Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration
2002-12-01

Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter

Article - wd:Q21144229

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