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Small-molecule inhibitors of dengue-virus entry

author

Stephen C. Harrison

1943 -

published in: PLOS Pathogens

date of publication: 2012

language: English

main subject: Dengue virus

Cites articles 33

Date

Title

Authors

2010-04-08

Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate

Stephen C. Harrison
2010-01-05

Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein
2010-09-29

Peptide inhibitors of flavivirus entry derived from the E protein stem

Stephen C. Harrison
2010-03-24

In vitro reconstitution reveals key intermediate states of trimer formation by the dengue virus membrane fusion protein

Claudia Sánchez-San Martín, Margaret Kielian
2009-12

A small molecule fusion inhibitor of dengue virus

Summer Zhang, Pei-Yong Shi, Jan Wilschut, Markus R. Wenk, Jolanda M Smit
2009-05

A small-molecule dengue virus entry inhibitor

Eric Vangrevelinghe, Deana Jaber, Thomas H. Keller, Subhash G Vasudevan, Qing-Yin Wang
2009-05

Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion

Michel Ledizet, Yorgo Modis
2009-11-01

Molecular mechanisms of flavivirus membrane fusion

Karin Stiasny
2009-09-23

In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses.

Boštjan Kobe, Ragothaman Yennamalli, Paul R Young, Martin J Stoermer, David P. Fairlie
2009-07-01

Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection
2009-02-25

Identification of novel target sites and an inhibitor of the dengue virus E protein

Boštjan Kobe, Ragothaman Yennamalli, Ross McGeary, Paul R Young
2008-12-19

Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein

Richard Kuhn
2008-08-14

Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins

Mark Cushman, Richard Kuhn
2008-12

Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells

Xiaowei Zhuang, Heidi van der Ende-Metselaar, Jan Wilschut, Jolanda M Smit, Hilde M van der Schaar
2008-12-11

A Stable Prefusion Intermediate of the Alphavirus Fusion Protein Reveals Critical Features of Class II Membrane Fusion

Margaret Kielian, Claudia Sánchez-San Martín
2008-10-20

Identification of specific histidines as pH sensors in flavivirus membrane fusion

Karin Stiasny
2008-07-01

Viral membrane fusion

Stephen C. Harrison
2007-08-29

Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking

Xiaowei Zhuang, Heidi van der Ende-Metselaar, Richard Kuhn, Jan Wilschut, Jolanda M Smit, Hilde M van der Schaar, Barry-Lee Waarts
2006-09-08

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

Robert T. Schooley, Stephen C. Harrison
2005-01-01

Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein

Yorgo Modis, Stephen C. Harrison
2005-01-01

Mechanism of membrane fusion by viral envelope proteins

Stephen C. Harrison
2004-02-25

Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation

Julien Lescar, Stéphane Duquerroy, Stéphane Bressanelli, Felix Rey, Enrico Stura, Karin Stiasny
2004-01-22

Structure of the dengue virus envelope protein after membrane fusion

Yorgo Modis, Stephen C. Harrison
2004-03-25

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
2003-11

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus

Jeroen Corver, Michael Rossmann, Richard Kuhn, Wei Zhang, Paul Chipman
2003-06-10

A ligand-binding pocket in the dengue virus envelope glycoprotein

Yorgo Modis, Stephen C. Harrison
2001-05

Mutational Evidence for an Internal Fusion Peptide in Flavivirus Envelope Protein E
2001-03-01

Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus

Felix Rey
1999-08-01

Therapeutic potential of blocking HIV entry into cells: focus on membrane fusion inhibitors
1998-11-01

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

J. Michael Kilby, Michael Saag, Dani Bolognesi
1995-05-25

The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution
1993-11-01

A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion

Article - wd:Q22583513

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