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DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications

forfatter

Edison Liu

Saul Kivimäe

udgivet i: Cancer Cell

dato for udgivelse: 2008-06

sprog: engelsk

main subject: cytologi, tyktarmskræft, Dishevelled binding antagonist of beta catenin 3, negative regulation of canonical Wnt signaling pathway, colorectal carcinoma

Cites articles 54

Date

Titel

Forfattere

2007-08-09

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

Hediye Erdjument-Bromage, Paul Tempst, Shau-Ping Lin, Charles David Allis
2007-08-02

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Eric Lander, Chad Nusbaum, Rudolf Jaenisch, Eric Mendenhall, Georgia Giannoukos, Carsten Russ, Marius Wernig, Alexander Meissner, Tarjei S Mikkelsen, Erez Lieberman Aiden, Bradley Bernstein, Xiaohui Xie
2007-06-15

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
2007-05-18

High-resolution profiling of histone methylations in the human genome

Artem Barski
2007-04

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

Svante Pääbo, Michael Weber
2007-02

Epigenetic stem cell signature in cancer
2007-02

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

Ravid Straussman
2007-09-01

Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells

Guillaume Bourque, Huck Hui Ng, Atif Shahab
2007-11-01

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome

Kenneth J. Pienta, Sooryanarayana Varambally
2007-04-16

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
2007-02-16

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

Riccardo Fodde
2007-01-01

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth

Jie Zheng, R. Kiplin Guy
2007-01-09

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

Linzhao Cheng, Thomas Jenuwein
2007-02-01

The many ways of Wnt in cancer
2007-01-01

WNT signaling in the normal intestine and colorectal cancer

Wim de Lau, Hans Clevers
2007-09-01

Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells.
2006-12-28

The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling

Ying Su, Meng Anming
2006-03-31

Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation
2006-02

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Stephen B. Baylin
2006-04-21

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Eric Lander, Rudolf Jaenisch, Robert Feil, Kathrin Plath, Marius Wernig, Tarjei S Mikkelsen, Bradley Bernstein, Stuart Schreiber, Michael Kamal, Xiaohui Xie
2006-07-06

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Jesús Espada, Esteban Ballestar, Manel Esteller
2006-03-29

Chromatin signatures of pluripotent cell lines

Véronique Azuara, Helle F. Jørgensen, Rosalind John, Mina Gouti, Miguel Casanova, Matthias Merkenschlager, Amanda Fisher
2006-12-01

Mining the Wnt pathway for cancer therapeutics
2006-09-01

Three Dact gene family members are expressed during embryonic development and in the adult brains of mice

Saul Kivimäe
2006-12-20

Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2.
2006-05-03

Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells.
2005-10-21

Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.
2005-04-01

Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations

Julien Mazieres
2004-05

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer

Irma Thesleff
2004

The Wnt signaling pathway in development and disease
2004-04

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Stephen B. Baylin, Hiromu Suzuki, Kohzoh Imai
2004-10-01

Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors

Artikel - wd:Q24319915

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