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Combinatorial biosynthesis of antitumor indolocarbazole compounds

författare

César Sánchez

Alfredo F. Braña

Carmen Méndez

publicerad i: Proceedings of the National Academy of Sciences

utgivningsår: 2005-01-11

språk: engelska

Refererar artiklar 36

Datum

Titel

Författare

2019-12-31

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin
2004-05-15

Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

Hagop Kantarjian, Francis Giles
2004-03-16

Accessing natural products by combinatorial biosynthesis
2004-03-01

Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412.
2004-02-01

Edotecarin
2003-12-01

Metabolic engineering for drug discovery and development
2003-01-01

Metabolic engineering--a genetic toolbox for small molecule organic synthesis
2003-07-01

Natural products as sources of new drugs over the period 1981-2002.

Gordon M. Cragg
2003-04-01

CEP-1347 (Cephalon)
2003-02-01

Rebeccamycin analogues as anti-cancer agents
2003-01-01

The biosynthesis of indolocarbazoles in a heterologous E. coli host

Jon S Thorson
2003-01

Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.
2002-12-01

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans
2002-10-01

Modification of post-PKS tailoring steps through combinatorial biosynthesis
2002-04-01

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

Alfredo F. Braña, Carmen Méndez
2002-06-01

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

Alfredo F. Braña, Carmen Méndez
2001-11-01

Altering the glycosylation pattern of bioactive compounds
2001-04-01

Microbial biosynthesis of halometabolites
2000-02-01

UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?
1999-06

Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication
1999-05-01

Calories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition

Jonathan B. Chaires
1998-09-01

Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin
1998-06-01

Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus

Carlos Olano
1998-10-01

Harnessing the biosynthetic code: combinations, permutations, and mutations
1996-09-01

Generation of polyketide libraries via combinatorial biosynthesis
1994-11-01

The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome-binding site.
1994-07-01

Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors
1994-03

Isolation and synthesis of 3,4-bis(indol-3-yl)pyrrole-2,5-dicarboxylic acid derivatives from the slime mould Lycogala epidendrum

Bert Steffan
1993-01-01

Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus
1993-01

A New Metabolite of Tryptophan, Chromopyrrolic Acid, Produced byChromobacterium violaceum
1991

Isolation of a bromo analog of rebeccamycin from Saccharothrix aerocolonigenes
1990-07-04

New colorimetric cytotoxicity assay for anticancer-drug screening

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