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Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

autor

Dennis J. Selkoe

1943 -

publicat în: Behavioural Brain Research

Data de publicare: 2008-09-01

Limbă: limba engleză

Subiectul principal: synaptic plasticity

Citează articole 72

Dată

Title

Autori

2007-03-14

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

Brenda L Bloodgood, Dennis J. Selkoe, Bernardo L. Sabatini
2007-09-13

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

Dennis J. Selkoe
2007-01-01

Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.

Brenda L Bloodgood, Bernardo L. Sabatini
2006-03-16

A specific amyloid-beta protein assembly in the brain impairs memory

Sylvain Lesné, Karen Ashe
2006-12-07

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
2006-06-11

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model

Cheryl Hawkes, Peter Henry St George-Hyslop
2006-02-09

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

Dennis J. Selkoe
2005-08-01

Regulation of NMDA receptor trafficking by amyloid-beta

Eun Young Choi, Cláudia Guimas Almeida, Gunnar K. Gouras, Paul Greengard, Angus C. Nairn
2005-01

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

Karen Ashe
2005-03-01

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation

Dennis J. Selkoe
2005-01-01

Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays
2005-04-17

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

Michael J Rowan, Dennis J. Selkoe
2004-09

LTP and LTD

Mark Bear
2004-06-09

Structural basis of long-term potentiation in single dendritic spines

Masanori Matsuzaki, Naoki Honkura, Haruo Kasai
2004-12-02

Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
2004-12-01

Bidirectional activity-dependent morphological plasticity in hippocampal neurons

Valentin Nägerl
2004-04-01

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease

Dennis W. Dickson, Mikio Shoji, Steven G. Younkin
2003

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
2003-08-18

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

William L. Klein
2003-11-01

Calcium/calmodulin-dependent protein kinase II contributes to activity-dependent filopodia growth and spine formation
2002-07-19

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

John Anthony Hardy, Dennis J. Selkoe
2002-04-04

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Michael J Rowan, Dennis J. Selkoe
2002-08-01

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

Bradley Hyman, Karen Ashe, Steven G. Younkin, Linda H Younkin
2002-10-25

Alzheimer's disease is a synaptic failure
2002-12-27

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

George Benedek
2002-07-15

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

Peter Henry St George-Hyslop
2002-07-01

Neurodegenerative disease: amyloid pores from pathogenic mutations.

Hilal Lashuel
2002-05-01

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

David M. Holtzman
2002-05-01

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus
2001-11-01

Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology
2001-04-01

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
2001-01-01

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease.

Eliezer Masliah

Articol - wd:Q24645994

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