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Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies

published in: Molecular and Cellular Biology

date of publication: 2014-10-01

language: English

Cites articles 126

Date

Title

Authors

2014-05-08

Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells

Michael Sierant, Yuanfang Guan
2014-04-29

Developmental transcriptome analysis of human erythropoiesis

Michael Sierant, Yuanfang Guan, Maureen Sartor
2014-03-24

PGC-1 coactivator activity is required for murine erythropoiesis

A Campbell
2014-03-10

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

Supat Thongjuea, Ralph Stadhouders, Eric Soler, Stephan Menzel, Boris Lenhard, Wilfred F J van IJcken, Swee Lay Thein
2014-01-23

The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells

George R Wendt, Takaaki Konuma, Atsushi Iwama
2013-10-01

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

Sophia C Kamran, Zhen Shao, Matthew C Canver, Luca Pinello, Jeff Vierstra
2013-10-03

TRIM28 is essential for erythroblast differentiation in the mouse
2013-05-28

Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing

Laura J Norton, Merlin Crossley, Andrew C Perkins
2013-04-01

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Jennifer J. Trowbridge
2013-02-19

Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model
2013-02-17

Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction
2013-11-01

Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus

Kyriacos Markianos, Gerard Berry
2012-06-28

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer Doudna, Emmanuelle Charpentier
2012

Mi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic mice
2012-12-10

Bcl11a is essential for lymphoid development and negatively regulates p53.

Neal G. Copeland, Nancy A. Jenkins, Walid T Khaled
2012-12-05

Seventy-five genetic loci influencing the human red blood cell

Tõnu Esko, David M. Evans, Leo-Pekka Lyytikäinen, Sandosh Padmanabhan, Inga Prokopenko, Daníel F. Guðbjartsson, John P Kemp, Christa Meisinger, Anna Dominiczak, Marjo-Riitta Järvelin, Braxton D. Mitchell, Alan R. Shuldiner, Peter M. Visscher, Panos Deloukas, Christian Gieger, Nicole Soranzo, Unnur Þorsteinsdóttir, Anke Tönjes, Anna-Liisa Hartikainen, Terho Lehtimäki, Serena Sanna, Jouke-Jan Hottenga, Alexander Teumer, Gonneke Willemsen, Anneli Pouta, Eleonora Porcu, Aimo Ruokonen, Philippe Froguel, Andres Metspalu, Manuela Uda, Claudia Langenberg, Angela Döring, Mika Kähönen, Thomas Illig, Harm-Jan Westra, Pim van der Harst, Vinicius Tragante, Niek Verweij, Gudmundur Ingi Eyjolfsson, Stuart Meacham, Daniela Ruggiero, François Bastardot, Dirk S Paul, Beben Benyamin, Francisco S Domingues, Clara Sze-Man Tang, Giorgia Girotto, Fabrice Danjou, Paul F. O'Reilly, Augusto Rendon, Teresa Nutile, Nicola Pirastu, Manuel A Ferreira, Lorna M. Lopez, Marina Ciullo, Jian Yang, Marleen H de Moor, Adamo Pio d'Adamo, Marcus E Kleber, Andrew A Hicks, Willem H. Ouwehand, Andres Salumets, Folkert Asselbergs, Sarah E. Medland, Lude Franke, Gunnar Engström, Jacques S Beckmann, Wiek H van Gilst, Grant W. Montgomery, Josef M Penninger, Ian Deary, Nick Martin, George Davey Smith, Uwe Völker, Francesco Cucca, Krista Fischer, Brenda Penninx, Hein Schepers, Bernd Genser, Stavroula Kanoni, Andreas Greinacher, Michael Stumvoll, Nicholas J. Wareham, Ruth J. Loos, Sheila Ulivi, Antonietta Robino, Luigi Ferrucci, Olle Melander, Dorret Boomsma, Patrick Sulem, Kay-Tee Khaw, Kári Stefánsson, Paul Elliott, Eco de Geus, Stefania Bandinelli, Peter Vollenweider, Dirk J van Veldhuisen, Ale Algra, Evelin Mihailov, Jaspal Kooner, Yasin Memari, James Scott, Susan Ring, Eric E Schadt, John Danesh, Tim Spector, Toshiko Tanaka, Abdel Abdellaoui, Harold Snieder, Olli Raitakari, John M Starr, Ilja M Nolte, Peter P. Pramstaller, Gerjan Navis, Miriam F Moffatt, Bruce H Wolffenbuttel, John B Whitfield, Antony P. Attwood, Paul I W de Bakker, Joban Sehmi, Liming Liang, Rob Sladek, Vasiliki Lagou, Irene Mateo Leach, Maria Dimitriou, Sian-Tsung Tan, Winfried Maerz, Janina S Ried, Matthias Nauck, Beverley Balkau, Carmel Moore, Afshin Parsa, Quince D Gibson, Jennifer Sambrook, Carsten Oliver Schmidt, Daniela Toniolo, Michela Traglia, Bernhard R. Winkelmann, Rossella Sorice, Federico Murgia, Giorgio Pistis, Sala Cinzia Felicita, Mario Pirastu, Hilma Holm, Ulrich Elling, Katrin Voss, Ramiro Ramirez-Solis, Martin Gögele, Jaana Hartiala, Hooman Allayee, Micha Hersch, Jennifer Jolley, Heather Lloyd-Jones, W.H. Wilson Tang, Stanley L Hazen, Lucas Joost, Aude Saint Pierre, Isleifur Olafsson, Rudolf Allert de Boer, Sarah E Harris, Ido P Kema, Johannes H Smit, Christian X Weichenberger, Claire E Hastie, Jonathan Stephens, Bernhard Otto Boehm, George Dedoussis, Jan Gustav Smith
2012-04-04

Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development

René Jüttner, Neal G. Copeland, Nancy A. Jenkins, Carmen Birchmeier
2011-01-25

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

Eric Lander, Harvey Lodish, Jo-Anne Vergilio
2011-01-28

The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor
2011-12-13

Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development

Christel Kockx, Supat Thongjuea, Ralph Stadhouders, Eric Soler, Boris Lenhard, Wilfred F J van IJcken, Mirjam C G N van den Hout, Frank Grosveld, Jan Christian Bryne, Charlotte Andrieu-Soler, Ernie de Boer, Robert-Jan Palstra, Anita van den Heuvel, Antoine A J van der Sloot
2011-10-31

Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes
2011-10-13

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

Zhen Shao, Gregory C Ippolito
2011-06-13

Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells

Jeroen Demmers
2011-03-08

A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression

Richard Sherva, Clinton Baldwin, Paola Sebastiani, Martin H Steinberg, Lindsay A. Farrer, Shau Yin Ha, David H K Chui
2011-11-17

Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia

Khaled M. Musallam, Ali Taher, Maria Domenica Cappellini
2010-09

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Pavlos Fanis, Petros Papadopoulos, Laura Gutiérrez, Joseph Borg, Godfrey Grech, Marianthi Georgitsi, Wilfred F J van IJcken, Christian Scerri, George P Patrinos
2010-10

Targeting DNA double-strand breaks with TAL effector nucleases

Adam Bogdanove
2010-03-01

A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E

Naoyuki Kamatani, Taisei Mushiroda, Chayanon Peerapittayamongkol, Surakameth Mahasirimongkol, Michiaki Kubo, Atsushi Takahashi, Yūsuke Nakamura, Natsuhiko Kumasaka
2010-10-23

siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures

Joseph DeSimone
2010-04-01

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.
2010-08-04

c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

Elisa Bianchi, Roberta Zini, Simona Salati, Elena Tenedini, Enrico Tagliafico, Rossella Manfredini, Sergio Ferrari
2010-08-01

KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching

Article - wd:Q26822810

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