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Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

author

Peiran Yang

Janet J. Maguire

Anthony P Davenport

published in: Trends in Pharmacological Sciences

date of publication: 2015-09-01

language: English

main subject: cardiovascular disease, hormone, peptide, bias, circulatory system, peptide hormone, toddler

Cites articles 112

Date

Title

Authors

2015-01

Identifying (non-)coding RNAs and small peptides: challenges and opportunities

Eivind Valen, Alexander F Schier, Andrea Pauli
2015-02-02

Elabela-apelin receptor signaling pathway is functional in mammalian systems

Wei Zheng, Alan R. Shuldiner
2015-06-01

Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling

Jan K Hennigs
2015-03-27

Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension
2015-02-23

Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist

Mervyn Singer, Janet J. Maguire, Peiran Yang, Alex Dyson, Joseph Cheriyan, Anthony P Davenport, Rubben Torella
2015-02-24

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action

Élie Besserer-Offroy
2014-04-02

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

István Szokodi
2014-09-30

Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling
2014-07-10

Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine

I Banegas, Xavier Iturrioz, Michel Bouvier, Catherine Llorens-Cortès
2014-01-09

Toddler: an embryonic signal that promotes cell movement via Apelin receptors

Megan L Norris, Guo-Liang Chew, James A Gagnon, Eivind Valen, Andrea Pauli, J. Keith Joung
2014-07-02

Effect of apelin on the cardiac hemodynamics in hypertensive rats with heart failure
2014-06-24

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension

Thomas Bertero, Rahul Kumar
2014-04-13

Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity.
2014-04-01

Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid
2014-03-27

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists

Xavier Iturrioz, Dominique Bonnet, Catherine Llorens-Cortès
2014-08-28

The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor
2014-10-30

New structural insights into the apelin receptor: identification of key residues for apelin binding

Romain Gerbier, Vincent Leroux, Pierre Couvineau, Catherine Llorens-Cortès, Xavier Iturrioz
2013-12-05

ELABELA: a hormone essential for heart development signals via the apelin receptor

Lena Ho
2013-10

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis
2013-07

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

Helen E Benson, Joanna L. Sharman, Adam J Pawson, Michael Spedding, Anthony P Davenport, Richard Neubig
2013-12-26

Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism
2013-08-09

Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity

Jan K Rainey
2013-11-01

Apelin is a positive regulator of ACE2 in failing hearts

Takashi Suzuki, Akiyoshi Fukamizu, Josef Penninger
2013-09-18

Apelin and its receptor APJ in cardiovascular diseases
2013-07-16

Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma
2013-07-15

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

Hirofumi Sawada, David E Solow-Cordero
2013-07-01

Effects of acute intravenous infusion of apelin on left ventricular function in dogs with advanced heart failure
2013-07-01

Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues

Shaun M K McKinnie, Josef Penninger, John Christopher Vederas, Ratnadeep Basu, Vijay Kandalam
2013-04-19

Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development

Thomas Quertermous
2013-04-01

Regulation of feeding behavior, gastrointestinal function and fluid homeostasis by apelin
2013-03-21

Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure

David E Newby
2013-03-01

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition

Article - wd:Q26823618

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