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Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents

published in: Clinical Microbiology Reviews

date of publication: 2013-04

language: English

Cites articles 158

Date

Title

Authors

2012-05-13

Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers

Maria B Grant, Hartmut Derendorf
2012-02-01

Positron emission tomography molecular imaging for drug development

Eugenii A. Rabiner, Roger N. Gunn, Paul M. Matthews
2012-09-04

Comparison of fluconazole renal penetration levels in healthy and Candida albicans-infected Wistar rats

Teresa Dalla Costa
2012-03-01

Effect of protein binding on the activity of voriconazole alone or combined with anidulafungin against Aspergillus spp. using a time-kill methodology

David Sevillano Fernández, Natalia González
2011-12-23

Compilation of 222 drugs' plasma protein binding data and guidance for study designs
2011-11-14

Blood, tissue, and intracellular concentrations of erythromycin and its metabolite anhydroerythromycin during and after therapy
2011-11-14

Penetration of doripenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers

Markus Alexander Zeitlinger
2011-08-17

Characterization of interaction kinetics between chiral solutes and human serum albumin by using high-performance affinity chromatography and peak profiling
2011-12-01

Validation of the cantharidin-induced skin blister as an in vivo model of inflammation
2011-05-12

Non-invasive imaging in experimental medicine for drug development

Roger N. Gunn, Paul M. Matthews
2011-12-01

The effect of critical illness on drug distribution

Hartmut Derendorf
2011-05-02

Protein binding: do we ever learn?

Hartmut Derendorf
2011-04-04

Efficacy of simulated cefditoren versus amoxicillin-clavulanate free concentrations in countering intrastrain ftsI gene diffusion in Haemophilus influenzae

Natalia González, David Sevillano Fernández, María-José Giménez, Luis Alou
2011-01-31

Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model

Diarmaid Hughes, Niels Frimodt-Møller
2011-11-01

Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story

Andrew A. Udy
2011-11-01

Optimal dose of vancomycin for treating methicillin-resistant Staphylococcus aureus pneumonia in critically ill patients
2010-06-01

Treatment of bacterial prostatitis.

Benjamin A. Lipsky
2010-06-01

Characterization of the binding of sulfonylurea drugs to HSA by high-performance affinity chromatography
2010-02-01

Plasma protein binding in drug discovery and development.
2010-03-01

Significance of protein binding in pharmacokinetics and pharmacodynamics

Hartmut Derendorf
2010-11-03

Augmented creatinine clearance in traumatic brain injury

Andrew A. Udy, Rob Boots, Jeffrey Lipman
2010-06-01

Brain microdialysis study of meropenem in two patients with acute brain injury

Sandrine Marchand, William Couet, Bertrand Debaene, Claire Dahyot-Fizelier, Olivier Mimoz
2010-09-30

Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.

Hartmut Derendorf
2010-03-07

Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro

Françoise Van Bambeke, Paul M Tulkens, Klaus Skovbo Jensen, Pierre Baudoux, Niels Frimodt-Møller
2010-04-01

On the influence of protein binding on pharmacological activity of drugs
2009-07-01

Antifungal pharmacokinetics and pharmacodynamics: bridging from the bench to bedside

William Hope
2009-04-13

Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis

Hartmut Derendorf
2009-03-10

Studies of imipramine binding to human serum albumin by high-performance affinity chromatography
2009-03-16

Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus

Youri Glupczynski
2009-03-01

Characterization of drug-protein interactions in blood using high-performance affinity chromatography
2009-03-01

Pharmacokinetic issues for antibiotics in the critically ill patient

Jason A. Roberts, Jeffrey Lipman
2009-01-01

Protein binding of antimicrobials: methods for quantification and for investigation of its impact on bacterial killing

Markus Alexander Zeitlinger

Article - wd:Q26827380

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