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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

author

Matej Durik

2000 -

published in: Nature

date of publication: 2016-02-03

language: English

main subject: lifetime

Cites articles 48

Date

Title

Authors

2015-12-01

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Bennett G Childs, Matej Durik
2015-08-22

Measures of Healthspan as Indices of Aging in Mice-A Recommendation

Rafael de Cabo, Peter S. Rabinovitch, Donald K. Ingram, Richard A Miller
2015-07-01

Forging a signature of in vivo senescence

Norman Sharpless
2015-02-04

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

Brian K Kennedy
2014-12-11

Spartan deficiency causes genomic instability and progeroid phenotypes

Jan M van Deursen, Darren J Baker
2014-12-11

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA

Marco Demaria, Sameh A Youssef, Francis Rodier, Judith Campisi, Eiji Hara
2014-05-01

The role of senescent cells in ageing
2013-07-01

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo

Brian K Kennedy
2013-04-18

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice

Jan M van Deursen, Darren J Baker
2013-01-01

Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model

Norman Sharpless, Nabeel Bardeesy, Allison M Deal, David B Darr, Jessica A Sorrentino, Diego H Castrillon, Janakiraman Krishnamurthy, Kelly J. Clark
2013-11-14

Programmed cell senescence during mammalian embryonic development.

Gonzalo Gómez-López, Isabel Varela-Nieto, Manuel Collado, Manuel Serrano, Antonio Maraver
2013-11-14

Senescence is a developmental mechanism that contributes to embryonic growth and patterning.

William M Keyes, James Sharpe, Alexandre Robert-Moreno
2012-12-27

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

Tobias Wijshake
2012-12-16

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Tobias Wijshake
2012-12-01

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer
2012-12-03

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

Andrew M. Harrison, Jan M van Deursen
2012-11-08

Aging, cellular senescence, and cancer
2012-10-15

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Katie Colbert Coate, Matthew J Potthoff, Ronald M. Evans, David Mangelsdorf
2012-05-07

Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains
2011-11-02

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Tobias Wijshake, Nathan K. LeBrasseur
2010-07

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
2010-08-15

Fat tissue, aging, and cellular senescence

Thomas von Zglinicki, Sundeep Khosla, Dean E Morbeck
2010-10-23

Ageing-induced decline in physical endurance in mice is associated with decrease in cardiac SUR2A and increase in cardiac susceptibility to metabolic stress: therapeutic prospects for up-regulation of SUR2A.
2009-08

Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

Joseph G. Ibrahim, Hanna K Sanoff
2009-07-16

Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection

Charles L. Howe
2008-08-01

Senescence of activated stellate cells limits liver fibrosis

Valery Krizhanovsky, Ross A. Dickins, Cornelius Miething
2008-03

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Linda Partridge, Janet Thornton, Faruk Ramadani, Eugene Schuster, Marc Claret, Rachel Batterham, Matthew D Piper, Klaus Okkenhaug, David Gems, Colin Selman, Dominic J Withers, Melanie Clements
2008-05-30

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
2008-01-15

The aging cardiomyocyte: a mini-review
2007-06-29

Does renal ageing affect survival?
2006-11-01

Transgenic mice with a reduced core body temperature have an increased life span

Tamas Bartfai, Raphaelle Winsky-Sommerer, Bruno Conti, Manuel Sanchez-Alavez, Maria Concetta Morale, Jacinta Lucero
2006-07-01

Physiology of local renin-angiotensin systems

Reinhold Kreutz

Article - wd:Q28005547

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