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High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

författare

Christian Grimm

Sami Hassan

2000 -

Hartmut Cuny

Bernd H Northoff

Oliver Griesbeck

publicerad i: Nature Communications

utgivningsår: 2014-08-21

språk: engelska

huvudämne: fettlever, leversjukdom

Refererar artiklar 60

Datum

Titel

Författare

2014-03-16

Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis

Ronit Shiri-Sverdlov
2014-02

Two-pore channels (TPCs): current controversies

Antony Giuseppe Galione
2014-02-05

Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases

Sandip Patel
2013-02-14

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state

Chunlei Cang, Lucy Shi, Betsy Navarro
2013-05-26

Cholesterol-binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1

Lennert Janssen
2013-02-06

Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature
2013-07-04

Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks

Peter F. Stadler, Daniel Teupser, David Langenberger, Joachim Thiery
2012-05-01

Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease

John A Kellum
2012-03-08

Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?
2012-05-01

Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export
2012-12-01

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
2012-10-12

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

David E Clapham
2012-08-02

Drosophila TRPML is required for TORC1 activation

Craig Montell
2012-03-13

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

Zepeng Yao, Hollis D Showalter
2012-11-19

Endosomal cholesterol trafficking: protein factors at a glance

Hongyuan Yang
2012-06-29

Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules

Stefan Heller
2011-10-28

Two-pore channels form homo- and heterodimers

Antony Giuseppe Galione
2011-11-01

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

Frances Platt, Antony Giuseppe Galione
2011-01-07

Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches
2010-01-01

Nonalcoholic fatty liver disease: pathology and pathogenesis

Elizabeth M. Brunt
2010-12-01

Endosome-lysosome fusion.
2010-03-25

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking

Frances Platt, Abdelilah Arredouani, Antony Giuseppe Galione, Lianne C Davis
2010-07-09

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

Martin Biel
2010-12-07

Planar patch clamp approach to characterize ionic currents from intact lysosomes.

Martin Biel
2010-11-05

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

Elisa Venturi, Samantha Pitt, A. Ganesan, Antony Giuseppe Galione
2010-02-01

Functional multimerization of mucolipin channel proteins.
2010-06-21

A cation counterflux supports lysosomal acidification

Tobias Stauber, Thomas Jentsch, Sergio Grinstein, Sabrina Jabs
2010-07-13

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
2010-01-31

Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction

Emily R. Eden, Clare E Futter
2009-10-01

The delivery of endocytosed cargo to lysosomes
2009-08-12

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Judith Klumperman
2009-05-28

NAADP mobilizes calcium from acidic organelles through two-pore channels

Zui Pan, Abdelilah Arredouani, Antony Giuseppe Galione

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