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Targeting the dynamic HSP90 complex in cancer

author

Giuseppe Giaccone

1955 -

Len Neckers

Jane B Trepel

published in: Nature Reviews Cancer

date of publication: 2010-08

language: English

Cites articles 170

Date

Title

Authors

2010-02-01

Asymmetric activation of the hsp90 dimer by its cochaperone aha1

Franz Hagn, Klaus Richter
2010-01-20

Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis

Atanas Koulov, Cheryl Arrowsmith
2010-02-01

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

Chrisostomos Prodromou, Len Neckers, Jane B Trepel, Bradley T Scroggins
2010-01-19

Cell polarity, Notch signaling and neurogenesis.
2010-01-14

The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells
2010-02-04

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

Valeria Specchia
2010-01-15

Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors

Charles Erlichman, Joleen M Hubbard
2010-04

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia
2010-02-22

Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors

Chandra Belani, Charles Erlichman
2010-02-01

An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors
2010-01-25

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab

Gabriela Chiosis, Eloisi Caldas-Lopes, Jason P. Holland, Jason S. Lewis
2010-04-15

Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

Marissa V Powers, Keith Jones, Caterina Barillari
2010-01-01

Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells

Brian Blagg
2010-01

Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer

Lucia R. Languino
2010-06-15

Hsp90 phosphorylation, Wee1 and the cell cycle

Len Neckers
2010-06-01

Heat shock protein 70 (hsp70) as an emerging drug target

Lyra Chang
2009-04-26

Novel Hsp90 partners discovered using complementary proteomic approaches

Stefan Rüdiger, Jeroen Krijgsveld
2009-01-14

Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression
2009-01-01

Update on Hsp90 inhibitors in clinical trial

Giuseppe Giaccone, Len Neckers, Jane B Trepel
2009-02-22

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

Thorsten Hugel
2009-02-22

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

Klaus Richter
2009-02-02

Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning

Paul Workman
2009-07-06

Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta

Pablo C Echeverria, Mario D Galigniana
2009-07-01

Expression of Hsp90 chaperone [corrected] proteins in human tumor tissue
2009-04-01

Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma

William M. Old, Rebecca Schweppe
2009-06

Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery
2009-03

Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer

Giulia Morra, Gennady Verkhivker, Giorgio Colombo
2009-08-21

Hsp90 is regulated by a switch point in the C-terminal domain

Christian H Eberl, J Beck
2009-12-16

Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility

Pablo C Echeverria
2009-12-01

Modulation of Hsf1 activity by novobiocin and geldanamycin

Renaud Condé
2009-12-01

Identification of inhibitors of HSF1 functional activity by high-content target-based screening
2009-03-23

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

Olivier Elemento, Leandro Cerchietti, Weimin Ci, Pedro Farinha, Jose M Polo, Randy D Gascoyne

Article - wd:Q28288602

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