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Inhibition of 2-oxoglutarate dependent oxygenases

author

Christopher J. Schofield

1960 -

Nathan R Rose

Michael A McDonough

Oliver King

Akane Kawamura

published in: Chemical Society Reviews

date of publication: 2011-03-10

language: English

Cites articles 200

Too many entities requested (224). Only 200 are displayed.

Date

Title

Authors

2010-08-20

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

Christopher J. Schofield, Christoph Loenarz
2010-12

Structural studies on human 2-oxoglutarate dependent oxygenases

Rasheduzzaman Chowdhury, Christopher J. Schofield, Christoph Loenarz, Michael A McDonough, Ian J Clifton
2010-12-01

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

Christopher J. Schofield, Ivanhoe K. H. Leung, Tobias Krojer, Grazyna Kochan, Luc Henry, Frank von Delft, Michael A McDonough
2010-01

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

John R Horton
2010-02-19

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

Udo Oppermann, Christopher J. Schofield, Christoph Loenarz, Michael A McDonough, Christopher D. Cooper, Wyatt W Yue
2010-10

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

Christopher J. Schofield, Refaat B. Hamed, Emily Flashman, Carsten Krebs, J. Martin Bollinger Jr.
2010-03-15

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

Christopher J. Schofield, Emily Flashman, Sarah L Davies
2010-03-01

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde

Richard J. Hopkinson, Refaat B. Hamed, Nathan R Rose, Christopher J. Schofield
2010-11-23

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

Udo Oppermann, Akane Kawamura, Christopher J. Schofield, Nathan R Rose, Bryan T Mott, Ajit Jadhav, Anton Simeonov, Oliver King
2010-05-21

Development of homogeneous luminescence assays for histone demethylase catalysis and binding

Christopher J. Schofield, Akane Kawamura, Nathan R Rose, Oliver King
2010-04-01

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation
2010-08-01

Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry

Christopher J. Schofield, Benedikt M. Kessler, Richard J. Hopkinson, Holger B. Kramer
2010-05

Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival

Peter Dedon
2010-11-15

The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA
2010-11-05

Expanding role of the jumonji C domain as an RNA hydroxylase

Osamu Nureki, Ryuichiro Ishitani
2010-02-25

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

Udo Oppermann, Christopher J. Schofield, Nathan R Rose, Michael A McDonough
2010-08-01

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors

Yukihiro Itoh
2010-10-15

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

Christopher J. Schofield, Christoph Loenarz, Michael A McDonough, Ian J Clifton, Kirsty S Hewitson, Luke A McNeill, Ana Conejo-García
2010-05-20

2-Oxoglutarate oxygenases are inhibited by a range of transition metals

Christopher J. Schofield, Nathan R Rose
2010-02-08

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
2010-02-18

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Patrick S. Ward, David R Wise, Omar Abdel-Wahab, Justin R. Cross, Cyrus V Hedvat
2010-08-05

IDH mutations in glioma and acute myeloid leukemia
2010-11-05

Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH)

Rachel J Hampton-Smith, Daniel J. Peet
2010-10-18

Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model

Christopher J. Schofield, Bernhard Schmierer
2010-09-01

Mildronate exerts acute anticonvulsant and antihypnotic effects

Marina Makrecka
2010-08-06

Crystal structure of human gamma-butyrobetaine hydroxylase

Kaspars Tars, Andris Kazaks
2010-09-01

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia
2010-03

The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells
2010-01-06

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Sarah O'Meara, Tatiana Mironenko, Syd Barthorpe, Gemma Buck, Sarah Edkins, Gillian L Dalgliesh, Bin Tean Teh, P. Andrew Futreal, Andrew Menzies, Jon Teague, Michael Stratton, Calli Latimer, David R. Jones, Helen Davies
2009-09-28

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II)

Nathan R Rose, Christopher J. Schofield, Jasmin Mecinovic
2009-05-01

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure

Christoph Loenarz, Jasmin Mecinovic, Frank Sobott, Christopher J. Schofield, Emily Flashman, Kar Kheng Yeoh
2009-06-04

Characterization of a robust enzymatic assay for inhibitors of 2-oxoglutarate-dependent hydroxylases.

Article - wd:Q28306956

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