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Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

auteur

Ryan Limbocker

Benedetta Mannini

Oskar Hansson

Sara Snogerup Linse

Tuomas Knowles

Michele Vendruscolo

Janet R Kumita

Chris Dobson

Johnny Habchi

Chia-Hsiung Cheng

gepubliceerd in: Proceedings of the National Academy of Sciences

publicatiedatum: 2016-12-23

taal: Engels

belangrijk thema: ziekte van Alzheimer

Cites articles 38

Date

Titel

Auteurs

2016-06-01

The amyloid hypothesis of Alzheimer's disease at 25 years

John Hardy, Dennis Selkoe
2016-09-18

Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele

Henrik Zetterberg, Kaj Blennow, Jan Borén, Erik Portelius
2016-02-12

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease

Chris Dobson, Michele Vendruscolo, Priyanki Joshi, Ana R Costa, Maho Yagi-Utsumi, Sara Snogerup Linse
2016-02-01

The Cellular Phase of Alzheimer's Disease

Bart De Strooper
2015-02-16

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

Jenny Presto, Chris Dobson, Michele Vendruscolo, Christopher J Dunning, Henrik Biverstal, Jan Johansson, Sara Snogerup Linse, Firoz Roshan Kurudenkandy, André Fisahn, Birgitta Frohm
2014-07-03

Alzheimer's disease drug-development pipeline: few candidates, frequent failures

Jeffrey Cummings
2014-06-01

The amyloid state and its association with protein misfolding diseases.

Chris Dobson, Michele Vendruscolo
2014-07-02

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

John Hardy
2014-02-20

Chemical kinetics for drug discovery to combat protein aggregation diseases

Chris Dobson, Michele Vendruscolo
2013-05-23

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

Sara Snogerup Linse, Daniel Otzen, Chris Dobson, Michele Vendruscolo
2013-07-01

Natural compounds may open new routes to treatment of amyloid diseases
2013-12-20

Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay

Sara Snogerup Linse, Tuomas Knowles, Birgitta Frohm, Risto Cukalevski
2012-03-16

Alzheimer mechanisms and therapeutic strategies

Lennart Mucke
2012-07-11

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

Peter R Schofield, Randall J Bateman, William E. Klunk, Nick C Fox, Alison Goate, David M. Holtzman, Martin Rossor, Ralph Martins, Richard Mayeux, Dominantly Inherited Alzheimer Network, John C. Morris, Anne M Fagan, Colin L. Masters, Paul Aisen, Daniel S. Marcus, Tammie L. Benzinger, Nigel J Cairns, Bernardino F. Ghetti, Reisa Sperling, Xianyun Xie, Tyler Blazey, Virginia D Buckles, Krista Moulder, Eric McDade, John M Ringman, Stephen Salloway, Anna Santacruz
2012-11-21

Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

Gawain McColl, Tara Pukala, Ashley I Bush, Blaine R Roberts, Colin L. Masters, Kevin J Barnham, Vijaya B Kenche
2012-03-08

From macroscopic measurements to microscopic mechanisms of protein aggregation

Chris Dobson, Michele Vendruscolo
2012-01-01

2012 Alzheimer's disease facts and figures
2012-01-01

Retinoid receptors and therapeutic applications of RAR/RXR modulators

William Bourguet, Hinrich Gronemeyer, Angel R de Lera
2012-01-01

Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia

Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Lennart Minthon, Peder Buchhave, Åsa K Wallin
2011-08-19

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011-04-16

Modulation of RXR function through ligand design

William Bourguet, Hinrich Gronemeyer, Angel R de Lera
2011-04-01

Alzheimer's disease: the challenge of the second century

Alison Goate, David M. Holtzman, John C. Morris
2011-03-18

Measuring Caenorhabditis elegans life span in 96 well microtiter plates

Gregory M Solis, M Petrascheck
2010-11-09

Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity
2009-10-09

Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process

Barry Boland, Sara Snogerup Linse
2007-02

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Christian Haass, Dennis Selkoe
2007-10-01

RAR and RXR modulation in cancer and metabolic disease

Hinrich Gronemeyer, Lucia Altucci, Angel R de Lera
2007-02-06

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct
2006-10-01

A century-old debate on protein aggregation and neurodegeneration enters the clinic

Hilal Lashuel
2005-06

Virtual Computational Chemistry Laboratory – Design and Description

Johann Gasteiger, Peter Ertl, Roberto Todeschini, Igor V Tetko
2005-02-25

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
2003-12-18

Folding proteins in fatal ways

Dennis Selkoe

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