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Prediction of Thorough QT study results using action potential simulations based on ion channel screens

auteur

Mark R Davies

Gary R. Mirams

David Gavaghan

1966 -

gepubliceerd in: Journal of Pharmacological and Toxicological Methods

publicatiedatum: 2014

taal: Engels

Cites articles 35

Date

Titel

Auteurs

2014-08-01

Replacing the thorough QT study: reflections of a baby in the bath water
2013-03-14

Chaste: an open source C++ library for computational physiology and biology

David Gavaghan, Alexander G Fletcher, Rafel Bordas, Joe Pitt-Francis, Nejib Zemzemi, James M. Osborne, Jonathan Cooper, Gary R. Mirams
2013-01-01

MICE models: superior to the HERG model in predicting Torsade de Pointes

Glenn Myatt
2013-05-05

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

David Gavaghan, Mark R Davies, Gary R. Mirams
2013-04-25

Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

David Gavaghan, Gary R. Mirams
2013-12-02

Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.
2012-11-01

Ions, equations and electrons: the evolving role of computer simulations in cardiac electrophysiology safety evaluations
2012-11-01

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing

Gary R. Mirams, Mark R Davies, Peter Kohl
2012-10-26

Development of a high-throughput electrophysiological assay for the human ether-à-go-go related potassium channel hERG.
2012-10-26

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment.

Mark R Davies, Mark R. Boyett
2011-05

Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation

Thomas O'Hara
2011-08-01

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms

John R Bankston, Natalia Trayanova, Crystal M Ripplinger
2011-07-06

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing

Peter John Hunter, Stephen J Granite, Charles Antzelevitch, Christian Bollensdorff, Elisabetta Cerbai, Mario Delmar, Dario DiFrancesco, Rodolphe Fischmeister, Tobias Hannes, Harding SE, José Jalife, Phillip Lord, Gary R. Mirams, Stanley Nattel, Søren-Peter Olesen, Alexander V Panfilov, Natalia A Trayanova, Frank B. Sachse, Peter Kohl
2011-06-15

Considerations for the use of cellular electrophysiology models within cardiac tissue simulations

David Gavaghan, Jonathan Cooper
2011-05-01

Novel approaches to assessing cardiac safety--proceedings of a workshop: regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs

Gary R. Mirams
2011-09-01

The 'overly-sensitive' heart: sodium channel block and QRS interval prolongation
2011-02-07

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk

David Gavaghan, Jonathan Cooper, Gary R. Mirams
2011-06-15

High-throughput functional curation of cellular electrophysiology models.

Jonathan Cooper, Gary R. Mirams, Steven Niederer
2011-12-01

Is it time for in silico simulation of drug cardiac side effects?

Gary R. Mirams
2010-08-31

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
2010-01-01

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk
2009-10-14

A novel computational model of the human ventricular action potential and Ca transient

Francesco Pasqualini, Donald M Bers
2009-07-18

Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation
2009-05-01

Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis

Antonio Zaza
2008-11-17

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity
2008-07-25

The CellML Model Repository.

Peter John Hunter
2007-11-06

Alfuzosin delays cardiac repolarization by a novel mechanism

Heather Eng
2006-03-01

hERG potassium channels and cardiac arrhythmia
2006-01-01

In vitro and in vivo models for testing arrhythmogenesis in drugs
2006-03-24

Alternans and spiral breakup in a human ventricular tissue model

Alexander V Panfilov
2005-08-29

Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve

Jonathan R. Silva
2005-10-01

International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice

Food and Drug Administration

Artike - wd:Q28649794

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