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Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

udgivet i: Journal of Neuroscience

dato for udgivelse: 2011-02-01

sprog: engelsk

main subject: LDL receptor related protein 1, Heparan sulfate proteoglycan 2, LDL receptor related protein associated protein 1, Low density lipoprotein receptor-related protein 1, Perlecan (heparan sulfate proteoglycan 2)

Cites articles 47

Date

Titel

Forfattere

2010-07-29

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking

Rodrigo A Fuentealba, Jin-Moo Lee, Mary J LaDu
2009-09-09

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation

Yoshiharu Takayama, Philippe Boucher, Michelle D Tallquist
2009

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence
2009-05

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
2009-11-23

Alzheimer's disease: synaptic dysfunction and Abeta
2009-11-12

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

Jin-Moo Lee, Carl Frieden
2009-10-13

Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake
2009-10-08

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway

Rodrigo A Fuentealba
2009-04-01

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

David M. Holtzman
2009-01-27

Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.
2009-09-01

Alzheimer's disease: another target for heparin therapy.

Maria Grazia De Simoni, Luigi Bergamaschini
2008-10-21

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells

Sumio Ohtsuki, Tetsuya Terasaki, David M. Holtzman, Tadafumi Hashimoto, Chiori Yabuki
2007-10-04

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
2007-09

Clearance of amyloid-beta by circulating lipoprotein receptors

Peter J Lenting, Alison Goate, David Perlmutter, Rashid Deane
2007-08-01

Cell-surface proteoglycans as molecular portals for cationic peptide and polymer entry into cells
2006-11-01

LRP in amyloid-beta production and metabolism
2006-07-01

Interactions between heparan sulfate and proteins: the concept of specificity

Ulf Lindahl
2005-09-01

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association

Ricardo Matute
2005-09-27

Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain

Claudio C Werneck
2004-07-01

Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory.

Sally A Frautschy
2004-04-01

Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease

Maria Grazia De Simoni, Luigi Bergamaschini
2003-11-01

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein

Daniel A. Lawrence, Thomas H. Bugge
2003-08-01

Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders

Pieter Wesseling, Jack van Horssen
2003-02-21

The low density lipoprotein receptor-related protein complexes with cell surface heparan sulfate proteoglycans to regulate proteoglycan-mediated lipoprotein catabolism
2003-10-01

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life

David M. Holtzman
2003-03-03

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ.

Tony Wyss-Coray
2002-11-01

Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease

Dennis J. Selkoe
2002-07-01

Heparin attenuates cytotoxic and inflammatory activity of Alzheimer amyloid-beta in vitro.

Maria Grazia De Simoni, Luigi Bergamaschini
2001-04

Alzheimer's disease: genes, proteins, and therapy
2001-09

LRP: a multifunctional scavenger and signaling receptor
2001-01-01

The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family
2001-02-01

Heparan sulfate: decoding a dynamic multifunctional cell regulator

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