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A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases

著者

Miguel C. Seabra

Alistair N Hume

Bassam R. Ali

2000 -

この作品が含まれる作品: 生化学的・生物物理学的研究コミュニケーション

出版日: 2010-05-13

言語: 英語

Cites articles 29

Date

タイトル

著者

2009-08

Rab GTPases as coordinators of vesicle traffic

Harald Stenmark
2007-05-01

Protein isoprenylation in biology and disease: general overview and perspectives from studies with genetically engineered animals

Dolores Pérez-Sala
2006-10-04

Hydrophobic modifications of Ras proteins by isoprenoid groups and fatty acids--More than just membrane anchoring
2006-03-16

Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras.
2006-01-09

Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases

Miguel C. Seabra
2006-11-18

Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation.

Bassam R. Ali, Miguel C. Seabra
2005-05-26

Statins and the risk of colorectal cancer

Gad Rennert
2005-02-01

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

Michael F. Olson
2004-11-23

Multiple regions contribute to membrane targeting of Rab GTPases

Miguel C. Seabra, Bassam R. Ali, Molly Strom
2003-12-01

Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway

Robert G. Parton, Timothy M Evans, Carol Wicking
2003-08-25

Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases

Abul K Tarafder, Alistair N Hume, Banafshé Larijani, Miguel C. Seabra
2003-02-06

Membrane targeting of Rab GTPases is influenced by the prenylation motif

Anita Q. Gomes, Alistair N Hume, Duarte C. Barral, Bassam R. Ali, Jose S. Ramalho, Miguel C. Seabra
2002-01-01

The discovery and development of atorvastatin, a potent novel hypolipidemic agent
2001-06-01

Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease

José B Pereira-Leal, Alistair N Hume, Miguel C. Seabra
2001-05-11

Structural mechanism for statin inhibition of HMG-CoA reductase

ヨハン・ダイゼンホーファー
2001-02-19

Rab27a regulates the peripheral distribution of melanosomes in melanocytes
2001-01-08

Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

Peter D'Eustachio
2000-08-01

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.

Miguel C. Seabra
1999-07-09

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi
1998-08-01

Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases
1998-03-01

Membrane association and targeting of prenylated Ras-like GTPases

Miguel C. Seabra
1996-03-01

Protein prenyltransferases

Miguel C. Seabra
1995-01-01

Pharmacology of competitive inhibitors of HMG-CoA reductase

Alberico L. Catapano, Alberto Corsini
1994-11-15

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes
1992-11

The discovery and development of HMG-CoA reductase inhibitors
1992-11-01

GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex

Channing Der
1992-10-01

Biosynthesis and characterization of (S)-and (R)-3-hydroxy-3-methylglutaryl coenzyme A
1991-03-08

rab5 controls early endosome fusion in vitro
1989-06-30

All ras proteins are polyisoprenylated but only some are palmitoylated

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