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Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override

autor

Tim J. Yen

publicat în: Cell Cycle

Data de publicare: 2013-04-24

Citează articole 31

Dată

Title

Autori

2012-07-24

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

Emmanouil Fokas
2012-06-29

Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine

Mitchell Smith, Tim J. Yen
2012-04-23

Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.

Alan Ashworth, Carlo Toniatti
2011-12-27

Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites
2009-11-04

Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancer

Laura Casorzo, Tiziana Venesio
2009-10-01

Relative contributions of chromatin and kinetochores to mitotic spindle assembly
2009-01-01

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Bill Denny, Brian D. Palmer
2008-08-01

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.
2008-01-29

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
2007-12-01

Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition
2007-01-07

Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo
2007-01-01

Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.
2005-08-01

Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine
2005-07-11

Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks

Thomas Helleday
2005-05-01

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

Thomas Helleday, Kasper Fugger
2004-04-01

G2 checkpoint abrogators as anticancer drugs
2004-09-01

Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic cata
2003-04-01

Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

Tim J. Yen
2001-07

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
2001-02-01

Improvements in cytogenetic slide preparation: controlled chromosome spreading, chemical aging and gradual denaturing
2001-08-02

Overexpression of cyclin A in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction
2000-11-16

Surfing the p53 network

Bert Vogelstein, David P. Lane
2000-05-01

UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines
1999-04-01

Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
1998-12-01

The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

Tim J. Yen
1996-09-01

Topoisomerase II alpha is associated with the mammalian centromere in a cell cycle- and species-specific manner and is required for proper centromere/kinetochore structure
1992-12-01

Kinetochore formation and behaviour following premature chromosome condensation
1988-11-01

Movement and segregation of kinetochores experimentally detached from mammalian chromosomes

Raymond P. Zinkowski
1982-05-01

Mechanism by which caffeine potentiates lethality of nitrogen mustard
1976-05-01

Fluorescence analysis of late DNA replication in mouse metaphase chromosomes using BUdR and 33258 Hoechst
1970-01-01

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

Articol - wd:Q30540593

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