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Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.

Autor

Eva-Maria Mandelkow

2000 -

Eckhard Mandelkow

1943 -

veröffentlicht in: Acta Neuropathologica Communications

Erscheinungsdatum: 2015-05-10

Zitiert Artikel 84

Datum

Titel

Autor

2014-10-15

Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer's disease

Charles Harrington
2014-10-15

The role of tau oligomers in the onset of Alzheimer's disease neuropathology

María C Cárdenas-Aguayo
2014-09-12

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

Eckhard Mandelkow
2014-02-20

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

Anatoly Starkov, Mariona Jové, Manuel Portero-Otin, Aurora Pujol, Nathalie Launay, Navneet Ammal Kaidery, M. Flint Beal, Magali Dumont
2014-01-21

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

Tara L Spires-Jones, Bradley Hyman, Rose Pitstick, George Carlson, Manuela Polydoro, Allyson D Roe
2014-01-01

Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies
2013-12-19

Tau-aggregation inhibitor therapy for Alzheimer's disease

Charles Harrington
2013-12-01

Biomarker modeling of Alzheimer's disease

David M. Holtzman, Clifford Jack
2013-11-26

Chaperone-mediated autophagy: roles in disease and aging

Ana Maria Cuervo, Esther Wong
2013-04-22

Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology

Eva-Maria Mandelkow
2013-03-13

Progress and developments in tau aggregation inhibitors for Alzheimer disease

Eckhard Mandelkow
2013-02-26

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

John Q. Trojanowski
2013-01-01

A meta-analysis of the efficacy of donepezil, rivastigmine, galantamine, and memantine in relation to severity of Alzheimer's disease

Simona Di Santo, Federica Prinelli, Fulvio Adorni, Carlo Caltagirone
2013-02-11

Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation.

Eckhard Mandelkow, Markus Zweckstetter, Michał Gajda
2012

Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice

Masato Hosokawa, Takashi Nonaka, Haruhiko Akiyama
2012-11-29

Making the brain glow: in vivo bioluminescence imaging to study neurodegeneration

Eva-Maria Mandelkow
2012-11-01

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70
2012-11-15

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors

Eckhard Mandelkow, Eva-Maria Mandelkow
2012-09-01

Fluid biomarkers in Alzheimer disease

Henrik Zetterberg, Kaj Blennow, Anne M Fagan
2012-08-01

Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models
2012-04-25

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

Eva-Maria Mandelkow, Ann Van der Jeugd, Tariq Ahmed
2012-04-01

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

Erin E Congdon, Karen E Duff
2012-01-01

Deciphering Alzheimer disease

Eckhard Mandelkow, David M. Holtzman, Dennis J. Selkoe
2012-09-25

Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein

Kris Pauwels, Annalisa Pastore
2012-05-18

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.

Sandhya P Koushika, Eckhard Mandelkow, Eva-Maria Mandelkow
2012-01-03

Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models.

Jean-Nicolas Audet
2011

Lack of effect of methylene blue in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
2011-08-19

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011-06-15

P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating

Tsuyoshi Miyakawa, Keizō Takao, John Q. Trojanowski, Tetsuya Suhara
2011-02-12

"Lest we forget you--methylene blue...".

Eckhard Mandelkow
2011-03

Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity
2011-01-01

Cellular and molecular actions of Methylene Blue in the nervous system

Georg A Petroianu

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