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A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.

author

Johannes S. Gach

Pascal Poignard

Donald N Forthal

published in: PLOS One

date of publication: 2013-08-26

language: English

main subject: antibody

Cites articles 75

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Title

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Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate

Nitish Agrawal
2013-01-01

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HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes
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Jean-Philippe Julien, Ivelin S. Georgiev, Stephanie Moquin, Chris Carrico, Jason Gorman, Tongqing Zhou, Saidi H Kapiga, Ian Andrew Wilson, John R. Mascola, Lai-Xi Wang, Barton Haynes, Gary Nabel, Zhi-Yong Yang, William R Schief, Peter D. Kwong, Mallika Sastry, Dennis R. Burton, Jason S McLellan, Andrew B Ward, James Arthos, Richard T. Wyatt, Jeffrey C Boyington, Kaifan Dai, Mark K. Louder, Marie Pancera, Sijy O'Dell, Yongping Yang, Mattia Bonsignori, John Crump, Wayne C Koff, Syed Shahzad-Ul-Hussan, Stephen D Schmidt, Laura M Walker, Carole A. Bewley, Sanjay Phogat, Robert K Louder, Jared Orwenyo, Baoshan Zhang, Young Do Kwon
2011-12-01

Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules

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2011-11-25

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

Jean-Philippe Julien, Alejandra Ramos, Sheng-Kai Wang, Katie Doores, Max Crispin, Ten Feizi, Yukishige Ito, Ian Andrew Wilson, Pascal Poignard, Chi-Huey Wong, William R Schief, Dennis R. Burton, Andrew B Ward, Rogier W Sanders, John P. Moore, Robyn L Stanfield, Albert Cupo, Robert Pejchal, Reza Khayat, Rafael S Depetris, Umesh Katpally, Andre J Marozsan, Christopher N Scanlan
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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Lawrence Shapiro, Ivelin S. Georgiev, Tongqing Zhou, Michel C. Nussenzweig, John R. Mascola, Joseph Sodroski, Gary Nabel, Zhi-Yong Yang, Peter D. Kwong, Andrés Finzi, Kaifan Dai, Yongping Yang, Johannes F Scheid
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Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

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2010-04-01

Carbohydrate vaccines: developing sweet solutions to sticky situations?

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2010-03-24

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2010-03-17

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2010-01-20

In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1
2010-01-01

Toward an antibody-based HIV-1 vaccine
2010-04-01

HIV vaccine development
2009-09-01

Challenges for structure-based HIV vaccine design

William R Schief
2009-09-01

Immunogenicity of HIV-1 envelope glycoprotein oligomers

William R Schief, Richard T. Wyatt
2009-11-20

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

John R. Mascola, Joseph Sodroski, Gary Nabel, Zhi-Yong Yang, Peter D. Kwong, Dennis R. Burton, Tongqing Zhou, James Arthos, Richard T. Wyatt, Marie Pancera, Sijy O'Dell, Ann J Hessell, Mei-Yun Zhang
2009-12-02

Influence of novel CD4 binding-defective HIV-1 envelope glycoprotein immunogens on neutralizing antibody and T-cell responses in nonhuman primates

John R. Mascola, Christopher Sundling, Richard T. Wyatt
2009-11-25

Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

Bette Korber, Tanmoy Bhattacharya, John R. Mascola, David C. Montefiori, Holly J. Moore, Francine E McCutchan, Victoria R Polonis, Michael S Seaman, Peter B Gilbert, Steve Self, Alan Lapedes
2009-11-10

Proline is not uniquely capable of providing the pivot point for domain swapping in 2G12, a broadly neutralizing antibody against HIV-1.

Paul Furtmüller

Article - wd:Q31132248

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