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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

author

Rachid Skouta

Eric D Lee

Nicholas P. Tatonetti

Brent R Stockwell

published in: eLife

date of publication: 2014-05-20

language: English

main subject: endoplasmic reticulum stress, Ferroptosis, molecular biology, ferroptosis

Cites articles 67

Date

Title

Authors

2014-03-14

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

Kenichi Shimada, Rachid Skouta, Paul A. Rosenberg, Andreas Linkermann, Donald C. Lo, Denise E. Dunn
2014-01-01

Regulation of ferroptotic cancer cell death by GPX4

Kenichi Shimada, Rachid Skouta, Vasanthi S Viswanathan, Clary B Clish, Stuart Schreiber, Virginia Cornish
2014-01-01

The role of iron and reactive oxygen species in cell death
2013-12-01

Modulation of oxidative stress as an anticancer strategy

Isaac Harris
2013-10-01

The emerging role of the Nrf2-Keap1 signaling pathway in cancer
2013-10-03

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

Anneleen Daemen, Kornelia Polyak, Joe W Gray
2013-10

Cancer drug resistance: an evolving paradigm
2013-05-22

Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells
2013-04-01

The ABCs of membrane transporters in health and disease (SLC series): introduction

Elspeth A Bruford
2013-04-08

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

Bruno Chauffert
2012-12

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione
2012-06-06

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

Osamu Nagano, Go J Yoshida, Kaoru Mogushi, Makoto Suematsu, Hideyuki Saya, Takeshi Motohara
2012-05-01

Ferroptosis: an iron-dependent form of nonapoptotic cell death

Scott J Dixon, Rachid Skouta
2012-04-18

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Alan Fersht, Andreas C Joerger, Rainer Wilcken, Frank M. Boeckler
2012-03-14

Data-driven prediction of drug effects and interactions

Nicholas P. Tatonetti, Roxana Daneshjou, Russ Altman
2012-08-17

Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo

Carole Nicco, Olivier Mir, Romain Coriat
2011-10-30

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
2011-09-11

Glutamate release by primary brain tumors induces epileptic activity

Stefanie Robel, Harald Sontheimer
2011-09-06

Modulatory profiling identifies mechanisms of small molecule-induced cell death

Adam J Wolpaw, Kenichi Shimada, Rachid Skouta, Uri David Akavia, Dana Pe'er
2011-08-12

Inhibition of xc⁻ transporter-mediated cystine uptake by sulfasalazine analogs

Rita Sattler, Jesse Alt, Barbara S Slusher
2011-08-17

Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis

Yasuteru Kondo, Jun Inoue
2011-05-13

Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression
2011-05-20

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
2011-03-16

The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond

Marcus Conrad
2011-03-08

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

Hideki Yagi, Osamu Nagano, Masanobu Oshima, Makoto Suematsu, Takeshi Motohara
2011-04-01

Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility

Dimitri De Bundel
2010-12-13

Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

Roland Eils, Anne Hamacher-Brady, Thomas Efferth
2010-05

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Steven Salzberg, Lior Pachter, Cole Trapnell, Barbara J. Wold
2010-06

Privileged scaffolds for library design and drug discovery
2009-12-02

Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma

Sharyn Katz
2009-10-19

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults

Vincent Bours, Sophie Vanbelle, Didier Martin
2009-06-01

Quantitative signal detection using spontaneous ADR reporting

Article - wd:Q33745283

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