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Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

published in: Trends in Cell Biology

date of publication: 2014-07-04

main subject: hypoxia, lipid

Cites articles 72

Date

Title

Authors

2014-01-01

Stressed to death - mechanisms of ER stress-induced cell death

Afshin Samali, Susan Logue
2013-11-01

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition

David A. Ford, Peter Tontonoz
2013-10

Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids

Nousheen Zaidi, Johannes V. Swinnen
2013-06-20

Cellular fatty acid metabolism and cancer

Almut Schulze, Rudolf Zechner
2013-05-24

Stearoyl co-A desaturase 1 as a ccRCC therapeutic target: death by stress
2013-05-01

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
2013-05-13

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Elisa de Stanchina, Jurre J Kamphorst, Justin R. Cross, Eileen White, Joshua D Rabinowitz
2013-05-12

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Dafna Bar-Sagi, Jeffrey Drebin
2013-04-01

Regulation of mTORC1 and its impact on gene expression at a glance

David M. Sabatini
2013-04-30

Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
2013-10

Adipose tissue and adipocytes support tumorigenesis and metastasis
2013-03-04

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

David Ron, Romain Volmer
2013-02-25

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

Heather R Christofk, Laurent Vergnes, Jorge Z. Torres, Linda Liau, Robert M. Prins, Thomas Graeber, Karen Reue
2013-02-01

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation
2013-01-23

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

Susana Ros, Barrie Peck, Michael Wakelam, Qifeng Zhang, Philip East, Adrian Harris
2013-06-27

Membrane lipid saturation activates IRE1α without inducing clustering.
2012-11-23

Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
2012-10-04

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Michael McManus
2012-08-01

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress

Paul Greengard, Aeid Igbaria, Ala Trusina, Nathaniel Heintz, Qizhi Tang, Myriam Heiman
2012

SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids
2012-03-15

Mature breast adipocytes promote breast cancer cell motility
2012-01-18

The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012-12-01

The tumor microenvironment at a glance

Fran Balkwill, Melania Capasso
2011-11-25

The unfolded protein response: from stress pathway to homeostatic regulation
2011-10-30

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Iris L Romero, Marcus E. Peter, Ernst Lengyel, Gökhan Hotamışlıgil, Gordon B. Mills
2011-09-27

Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
2011-07-20

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
2011-06-13

Cancer cachexia: mechanisms and clinical implications

Aoife M Ryan, Claire L Donohoe, John V Reynolds
2011-07-01

Normalization of the vasculature for treatment of cancer and other diseases

Rakesh Jain
2011-05-01

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

Ling Yang, Oliver Hofmann, Winston Hide, Gökhan Hotamışlıgil
2011-04-19

Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle
2011-03

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

Article - wd:Q33955139

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