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T-cell exhaustion: characteristics, causes and conversion

author

Maureen Cox

published in: Immunology

date of publication: 2010-02-23

Cites articles 98

Date

Title

Authors

2009-12-01

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

Danielle Thierry-Mieg, Jean Thierry-Mieg, David E Levy, Stephen L. Nutt, Kathryn Calame
2009-11-30

Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study

Ali Ahmad, Cécile Tremblay, Alexandre Iannello, Mohamed-Rachid Boulassel, Suzanne Samarani, Jean-Pierre Routy, Olfa Debbeche
2009-11-08

CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help

Akiko Iwasaki
2009-10-30

On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection

Annette Oxenius
2009-10-01

IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age span
2009-09-02

Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy

Julia E Rood, Claire W Hallahan
2009-08-06

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection

Haina Shin, Andrew Intlekofer
2009-07-01

Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo

Roberto Tinoco
2009-07-08

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

Lucy Golden-Mason, Vijay Kuchroo
2009-07-02

mTOR regulates memory CD8 T-cell differentiation

Rafi Ahmed
2009-06-01

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
2009-06-03

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Gretchen Harms Pritchard
2009-05-28

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection.

Stefan Freigang, Manfred Kopf, Jan Kisielow, Annette Oxenius
2009-05-14

A vital role for interleukin-21 in the control of a chronic viral infection
2009-05-11

High antigen levels are the cause of T cell exhaustion during chronic viral infection

Rafi Ahmed
2009-05-07

IL-21 is required to control chronic viral infection
2009-05-06

Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression.

Christian Schürch
2009-04-13

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

Mark A. Brockman, Sylvie Le Gall, Bruce D. Walker, Florencia Pereyra
2009-04-01

Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection
2009-03-01

Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection

Pamela J. Skinner, Sang-Jun Ha, Rafi Ahmed, Cavan S. Reilly
2009-02

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

David A Price, Gordon J. Freeman, Emma Gostick
2008-06-01

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression

Kristin Ladell
2008-04-01

Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection

Elżbieta Tryniszewska, Jean-Michel Héraud, Richard A Koup
2008-12-01

Interleukin-35: odd one out or part of the family?
2008-12-10

Enhancing SIV-specific immunity in vivo by PD-1 blockade

Rafi Ahmed, Rama Rao Amara, Gordon J. Freeman
2008-12-15

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

Sang-Jun Ha, Gordon J. Freeman, Arlene Sharpe
2008-11-30

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

Haina Shin, W Nicholas Haining, Gordon J. Freeman, Dario Vignali, Michael R. Betts
2008-11-10

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

Aashish R Jha, Rupert Kaul, Tae-Wook Chun, Colin Kovacs, Mona R. Loutfy
2008-09-22

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

Haina Shin, Gordon J. Freeman
2008-06

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

David E. Kaplan, David A Price, Gordon J. Freeman, Emma Gostick
2008-07-01

PD-1 expression and IL-2 loss of cytomegalovirus- specific T cells correlates with viremia and reversible functional anergy
2008-08

Differences in Hepatitis C Virus (HCV)-Specific CD8 T-Cell Phenotype during Pegylated Alpha Interferon and Ribavirin Treatment Are Related to Response to Antiviral Therapy in Patients Chronically Infected with HCV

Artur Paiva

Article - wd:Q34102010

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