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Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

লেখক

Douglas Palmer

Steven Rosenberg

1940 -

Nicholas P. Restifo

Pawel Muranski

Luca Gattinoni

Zachary A Borman

Sid P Kerkar

Robert N Reger

Giorgio Trinchieri

এতে প্রকাশিত: Cancer Research

তারিখে প্রকাশিত: 2010-07-20

ভাষা: ইংরেজি ভাষা

মূল বিষয়: interleukins

Cites articles 50

তারিখ

শিরোনাম

লেখকগণ

2010-01-01

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

Douglas Palmer, Steven Rosenberg, Nicholas P. Restifo, Chrystal M Paulos, Claudia Wrzesinski, Pawel Muranski, Luca Gattinoni
2010-04-18

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

Reno Debets
2009-12-22

Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
2009-09-24

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity

Douglas Palmer, Nicholas P. Restifo, Steven Rosenberg, Christian S Hinrichs, Lydie Cassard, Pawel Muranski, Luca Gattinoni, Zachary A Borman, Rosanne Spolski, Steven E Kern, Robert N Reger, Warren J Leonard, Robert L Danner
2009-07

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

Douglas Palmer, Nicholas P. Restifo, Chrystal M Paulos, Claudia Wrzesinski, Christian S Hinrichs, Lydie Cassard, Pawel Muranski, Luca Gattinoni
2009-03

Myeloid-derived suppressor cells as regulators of the immune system
2009-02-01

IL-12 enhances CTL synapse formation and induces self-reactivity
2008-11-10

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

Nicholas P. Restifo, Steven Rosenberg, John R Wunderlich, Udai S Kammula, Marybeth S Hughes, Carolyn Laurencot, Stephanie G Downey, Jacob A Klapper
2008-04-01

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells

Paola Zanovello
2008-04-01

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
2007-11-01

Immunotherapy of cancer by IL-12-based cytokine combinations
2007-08-01

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

Marcello Chieppa, Douglas Palmer, Nicholas P. Restifo, Steven Rosenberg, Chrystal M Paulos, Claudia Wrzesinski, Christian S Hinrichs, Lydie Cassard, Pawel Muranski, Luca Gattinoni
2007-01-29

In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor

Alexandre Boissonnas, Sebastian Amigorena
2007-01-08

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

Ralph Weichselbaum
2006-01-01

Mechanisms of immune evasion by tumors

Elizabeth Jaffee
2006-12-01

Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation

Andrew Intlekofer
2005-10-03

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

Douglas Palmer, Steven Rosenberg, Charles Surh, Christopher A. Klebanoff, Nicholas P. Restifo, Claudia Wrzesinski, Luca Gattinoni, David Heimann, Leroy N Hwang
2005-04-01

Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions

Steven Rosenberg
2005-04

Immunosuppressive networks in the tumour environment and their therapeutic relevance
2005-03-01

CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells

Christopher A. Klebanoff, Steven Rosenberg
2005-03-01

Intratumoral recombinant human interleukin-12 administration in head and neck squamous cell carcinoma patients modifies locoregional lymph node architecture and induces natural killer cell infiltration in the primary tumor

Michiel Balvers
2004-12-14

Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas

Jesús Prieto, Carlos Alfaro, Bruno Sangro, Maite Herráiz, Ignacio Melero, MD-PhD, Alberto Benito, Ainhoa Arina, Iñigo Tirapu, Josu Sola, Esperanza Feijoó, Guillermo D Mazzolini, Cristina Olagüe, Belén Sádaba
2004-07-01

Genetic modification of T lymphocytes for adoptive immunotherapy

Malcolm K Brenner
2004-02-01

A strategy for treatment of Epstein-Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells

Catherine M Bollard, Cliona M Rooney, Malcolm K Brenner, Helen Heslop, M Helen Huls
2003-08-01

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells

Douglas Palmer, Christopher A. Klebanoff, Nicholas P. Restifo, Steven Rosenberg, Deborah R Surman, Marc R Theoret, David Heimann, Willem W Overwijk, Leroy N Hwang, Lionel Feigenbaum
2003-10-01

Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity

Hideho Okada
2003-10-01

IL-12 regulates an endothelial cell-lymphocyte network: effect on metalloproteinase-9 production,IL-12 Regulates an Endothelial Cell-Lymphocyte Network: Effect on Metalloproteinase-9 Production
2002-08-22

Autologous and MHC class I-negative allogeneic tumor cells secreting IL-12 together cure disseminated A20 lymphoma
2002-06-01

IL-12/IL-2 combination cytokine therapy for solid tumours: translation from bench to bedside
2002-04-01

Interleukin-12 in anti-tumor immunity and immunotherapy

Mario Paolo Colombo, Giorgio Trinchieri
2002-01-01

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

Laurie Glimcher
2001-03-01

IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk

নিবন্ধ - wd:Q34109953

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